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217695 Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one

Primary Target: Cdk1
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      220749-41-7C₁₇H₁₁ClN₂O
      Description
      Overview

      This product has been discontinued.



      A cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 µM HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of Cdk1/cyclin B (IC50 = 5.8 µM). Also inhibits Cdk5 with a IC50 = 25 µM. Binds to the ATP pocket on the Cdk1 active site. Does not affect the activity of GSK-3β even at 100 µM concentrations.
      Catalogue Number217695
      Brand Family Calbiochem®
      Synonyms3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one
      References
      ReferencesAndreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
      Andreani, A., et al. 1996. Anticancer Res. 16, 3585.
      Product Information
      CAS number220749-41-7
      ATP CompetitiveY
      FormOrange solid
      Hill FormulaC₁₇H₁₁ClN₂O
      Chemical formulaC₁₇H₁₁ClN₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk1
      Primary Target IC<sub>50</sub>2 µM for anti-proliferative properties in HeLa cells; 5.8 µM against Cdk1/cyclin B
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      217695 0

      Documentation

      Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk1 Inhibitor - CAS 220749-41-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      217695

      References

      Reference overview
      Andreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
      Andreani, A., et al. 1996. Anticancer Res. 16, 3585.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-December-2009 RFH
      Synonyms3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one
      DescriptionA cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties (IC50 = 2 µM in HeLa cells). Acts as a selective, reversible and ATP-competitive inhibitor of cyclin-dependent kinase-1/cyclin B (IC50 = 5.8 µM for Cdk1 and 25 µM for Cdk5). Does not affect the activity of GSK-3β even at 100 µM concentrations. Binds to the ATP pocket in the Cdk1 active site.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number220749-41-7
      Chemical formulaC₁₇H₁₁ClN₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAndreani, A., et al. 2000. Anticancer Drug Des. 15, 447.
      Andreani, A., et al. 1996. Anticancer Res. 16, 3585.