217697 Cdk1 Inhibitor III

217697
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₀H₁₅NO₄440362-74-3
      Description
      Overview

      This product has been discontinued.



      A cell-permeable 1-aza-9-oxafluorene compound that acts as a highly selective Cdk1/cyclin B inhibitor (IC50 = 28.8 µM) with very little activity against Cdk5/p25, Cdk2/E, or Cdk4/D1. Unlike other Cdk inhibitors, it exhibits potent inhibitory effect against P-glycoprotein-mediated MDR (multidrug resistance) in cancer cells (~9-fold more potent than verapamil). Its special bifunctional cytostatic property makes it an excellent tool for research in cancer treatment.

      Catalogue Number217697
      Brand Family Calbiochem®
      SynonymsEthyl-(6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b])pyridine-3-carboxylate
      References
      ReferencesBrachwitz, K., et al. 2003. J. Med. Chem. 46, 876.
      Product Information
      CAS number440362-74-3
      FormBrown powder
      Hill FormulaC₂₀H₁₅NO₄
      Chemical formulaC₂₀H₁₅NO₄
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetCdk1/cyclin B
      Primary Target IC<sub>50</sub>28.8 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cdk1 Inhibitor III SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk1 Inhibitor III Certificates of Analysis

      TitleLot Number
      217697

      References

      Reference overview
      Brachwitz, K., et al. 2003. J. Med. Chem. 46, 876.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      SynonymsEthyl-(6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b])pyridine-3-carboxylate
      DescriptionA cell-permeable, highly selective Cdk1/cyclin B inhibitor (IC50 = 28.8 µM). Exhibits only low inhibitory activity against Cdk5/p25, Cdk2/cyclin E, and Cdk4/cyclin D1. Unlike other Cdk inhibitors has also been reported to have potent inhibitory effects on P-glycoprotein-mediated multidrug resistance (MDR) in cancer cells (~9-fold more potent than verapamil). Its unique bifunctional cytostatic properties make it an attractive tool in cancer research.
      FormBrown powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number440362-74-3
      Chemical formulaC₂₀H₁₅NO₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml) or Ethanol (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesBrachwitz, K., et al. 2003. J. Med. Chem. 46, 876.