217699 Cdk1 Inhibitor IV, RO-3306 - Calbiochem

217699
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₁₃N₃OS₂

Pricing & Availability

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217699-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥ 2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. Also available as a 10 mM solution in DMSO (Cat. No. 217721).
      Catalogue Number217699
      Brand Family Calbiochem®
      References
      ReferencesVassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
      Product Information
      ATP CompetitiveY
      FormBrown solid
      Hill FormulaC₁₈H₁₃N₃OS₂
      Chemical formulaC₁₈H₁₃N₃OS₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk1
      Primary Target K<sub>i</sub>35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cdk1 Inhibitor IV, RO-3306 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk1 Inhibitor IV, RO-3306 - Calbiochem Certificates of Analysis

      TitleLot Number
      217699

      References

      Reference overview
      Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-June-2007 JSW
      DescriptionA cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines.
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₃N₃OS₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesVassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.