219448 Cdk2/5 Inhibitor

219448
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₁₀H₁₁N₅O₂S · HCl21886-12-4
      Description
      Overview

      This product has been discontinued.





      An aminopyrimidine derivative that acts as a selective and ATP-competitive inhibitor of Cdk2/cyclin E and Cdk5/p25 (Ki = 2 µM). Binds to the ATP-binding pocket of Cdk2. Does not affect the activities of c-Met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase, and ERK2 at concentrations as high as 100 µM.
      Catalogue Number219448
      Brand Family Calbiochem®
      SynonymsPNU 112455A, N⁴-(6-Aminopyrimidin-4-yl)-sulfanilamide, HCI
      References
      ReferencesClare, P.M., et al. 2001. J. Biol. Chem. 276, 48292.
      Product Information
      CAS number21886-12-4
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₀H₁₁N₅O₂S · HCl
      Chemical formulaC₁₀H₁₁N₅O₂S · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetCDK2
      Primary Target K<sub>i</sub>2 µM for Cdk2/cyclin E and Cdk5/p25
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cdk2/5 Inhibitor SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk2/5 Inhibitor Certificates of Analysis

      TitleLot Number
      219448

      References

      Reference overview
      Clare, P.M., et al. 2001. J. Biol. Chem. 276, 48292.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      SynonymsPNU 112455A, N⁴-(6-Aminopyrimidin-4-yl)-sulfanilamide, HCI
      DescriptionAn aminopyrimidine derivative that acts as a selective inhibitor of Cdk2/cyclin E and Cdk5/p25 (Ki = 2 µM). The inhibition is competitive with respect to ATP. Crystallographic studies indicate that the inhibitor binds to the ATP-binding pocket of the enzyme. Does not affect the activity of c-met, insulin-like growth factor I receptor tyrosine kinase (IGF-IR), cAMP-dependent kinase, or ERK2 even at a 100 µM concentration.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number21886-12-4
      Chemical formulaC₁₀H₁₁N₅O₂S · HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesClare, P.M., et al. 2001. J. Biol. Chem. 276, 48292.