220557 Chlorhexidine, Dihydrochloride

220557
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₂₂H₃₀Cl₂N₁₀ · 2HCl3697-42-5
      Description
      Overview

      This product has been discontinued.





      An anti-microbial agent that acts as an inhibitor of MMP-2 and MMP-9; however, MMP-2 is more sensitive to chlorhexidine than MMP-9. Inhibits the collagenase activity of MMP-8 released by PMA-triggered polymorphonuclear leukocytes (PMNs) in a dose-dependent manner. CHX may possibly act through a cation-chelating mechanism.
      Note: presence of CaCl2 in the medium blocks the inhibitory activity of CHX.
      Catalogue Number220557
      Brand Family Calbiochem®
      Synonyms1,6-bis[Nʹ-(p-Chlorophenyl)-N⁵-biguanido]hexane, 2HCl, CHX
      References
      ReferencesGendron, R., et al. 1999. Clin. Diagn. Lab. Immunol. 6, 437.
      Product Information
      CAS number3697-42-5
      FormWhite solid
      Hill FormulaC₂₂H₃₀Cl₂N₁₀ · 2HCl
      Chemical formulaC₂₂H₃₀Cl₂N₁₀ · 2HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetMMP-2, MMP-9
      Secondary targetMMP-8 collagenase activity
      Purity≥95% by titration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXA5285000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Chlorhexidine, Dihydrochloride SDS

      Title

      Safety Data Sheet (SDS) 

      Chlorhexidine, Dihydrochloride Certificates of Analysis

      TitleLot Number
      220557

      References

      Reference overview
      Gendron, R., et al. 1999. Clin. Diagn. Lab. Immunol. 6, 437.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      Synonyms1,6-bis[Nʹ-(p-Chlorophenyl)-N⁵-biguanido]hexane, 2HCl, CHX
      DescriptionAn antimicrobial agent. Acts as an inhibitor of MMP-2 and MMP-9, however, MMP-2 is more sensitive to chlorhexidine than MMP-9. Inhibits the collagenolytic activity of MMP-8 released by PMA-triggered polymorphonuclear leukocytes (PMNs) in a dose-dependent manner. CHX may possibly act through a cation-chelating mechanism.

      Note: Presence of CaCl2 in the medium blocks the inhibitory activity of CHX.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number3697-42-5
      RTECSXA5285000
      Chemical formulaC₂₂H₃₀Cl₂N₁₀ · 2HCl
      Structure formulaStructure formula
      Purity≥95% by titration
      SolubilityDMSO. It takes about 15 min. to completely dissolve the solid at 1 mg/ml in DMSO. Requires more time for complete solubilization at higher concentrations.
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      Merck USA index14, 2091
      ReferencesGendron, R., et al. 1999. Clin. Diagn. Lab. Immunol. 6, 437.