234115 Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem

234115
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₂H₂₅NO₆64-86-8

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234115-1GM
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      Alu drum 1 gm
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      234115-5GM
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          5 gm
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          Description
          OverviewInhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells.
          Catalogue Number234115
          Brand Family Calbiochem®
          References
          ReferencesBonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
          Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
          Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
          Santell, L. 1992. Exp. Cell Res. 201, 358.
          Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.
          Product Information
          CAS number64-86-8
          ATP CompetitiveN
          FormYellow or off-white powder
          Hill FormulaC₂₂H₂₅NO₆
          Chemical formulaC₂₂H₂₅NO₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetInhibitor of mitosis
          Purity≥94% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGH0700000
          Safety Information
          R PhraseR: 26/28

          Very toxic by inhalation and if swallowed.
          S PhraseS: 13-45

          Keep away from food, drink and animal feeding stuffs.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Colchicine, Colchicum autumnale - CAS 64-86-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          234115

          References

          Reference overview
          Bonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
          Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
          Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
          Santell, L. 1992. Exp. Cell Res. 201, 358.
          Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-October-2009 RFH
          DescriptionMajor alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells.
          FormYellow or off-white powder
          CAS number64-86-8
          RTECSGH0700000
          Chemical formulaC₂₂H₂₅NO₆
          Structure formulaStructure formula
          Purity≥94% by HPLC
          SolubilityEthanol (10 mg/ml) or H₂O
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 2471
          ReferencesBonfoco, E., et al. 1995. Exp. Cell Res. 218, 189.
          Lindenboim, L., et al. 1995. J. Neurochem. 64, 1054.
          Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res. 16, 929.
          Santell, L. 1992. Exp. Cell Res. 201, 358.
          Salmon, E.D., et al. 1984. J. Cell Biol. 99, 1066.