30967 Diisopropylfluorophosphate

30967
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical FormulaCAS #
      C₆H₁₄FO₃P55-91-4
      Description
      Overview

      This product has been discontinued.



      Please refer to our complete listing of cholinesterase inhibitors for possible alternatives.






      Serine protease inhibitor. A potent, irreversible inactivator of acetylcholinesterase that can cross the blood-brain barrier. Selectively blocks T cell receptor-triggered programmed cell death in murine T cell hybridoma and in activated peripheral T cells.
      Density: 1.055 g/ml
      Effective concentration: 100 µM; t½ = 1 h at pH 7.5. Use caution upon opening. May develop pressure. Use only if colorless.
      Catalogue Number30967
      Brand Family Calbiochem®
      SynonymsDFP
      References
      ReferencesOshikawa, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 2186.
      Takahashi, M., et al. 1994. Mol. Reprod. Dev. 38, 310.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Sikder, A.K., et al. 1993. J. Pharmacol. Sci. 82, 258.
      Ho, K., and Hoskins, B. 1983. Drug Chem. Toxicol. 6, 421.
      Cohen, J.A., et al. 1967. Methods Enzymol. 11, 686.
      Product Information
      CAS number55-91-4
      FormColorless liquid
      Hill FormulaC₆H₁₄FO₃P
      Chemical formulaC₆H₁₄FO₃P
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥98% by P-NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSTE5075000
      Safety Information
      R PhraseR: 26/27/28-34

      Very toxic by inhalation, in contact with skin and if swallowed.
      Causes burns.
      S PhraseS: 26-28-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsNote: use caution while opening; may develop pressure. Use only if colorless. Following reconstitution, aliquot and freeze (-70°C). Aqueous and DMSO stock solutions are highly unstable.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Diisopropylfluorophosphate Certificates of Analysis

      TitleLot Number
      30967

      References

      Reference overview
      Oshikawa, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 2186.
      Takahashi, M., et al. 1994. Mol. Reprod. Dev. 38, 310.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Sikder, A.K., et al. 1993. J. Pharmacol. Sci. 82, 258.
      Ho, K., and Hoskins, B. 1983. Drug Chem. Toxicol. 6, 421.
      Cohen, J.A., et al. 1967. Methods Enzymol. 11, 686.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-September-2008 JSW
      SynonymsDFP
      DescriptionSerine protease inhibitor. Irreversibly inactivates acetylcholinesterase. Selectively blocks T cell receptor-triggered programmed cell death in murine T-cell hybridoma and in activated peripheral T-cells. Commonly used at a concentration of 100 µM. Density: 1.055 g/ml.
      FormColorless liquid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number55-91-4
      RTECSTE5075000
      Chemical formulaC₆H₁₄FO₃P
      Structure formulaStructure formula
      Purity≥98% by P-NMR
      SolubilityIsopropanol (50 mg/ml)
      Storage -20°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsNote: use caution while opening; may develop pressure. Use only if colorless. Following reconstitution, aliquot and freeze (-70°C). Aqueous and DMSO stock solutions are highly unstable.
      Toxicity Highly Toxic
      Merck USA index14, 5176
      ReferencesOshikawa, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 2186.
      Takahashi, M., et al. 1994. Mol. Reprod. Dev. 38, 310.
      Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
      Sikder, A.K., et al. 1993. J. Pharmacol. Sci. 82, 258.
      Ho, K., and Hoskins, B. 1983. Drug Chem. Toxicol. 6, 421.
      Cohen, J.A., et al. 1967. Methods Enzymol. 11, 686.