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324840 EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem

The EGFR/ErbB-2/ErbB-4 Inhibitor, also referenced under CAS 881001-19-0, controls the biological activity of EGFR/ErbB-2/ErbB-4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-((3-Chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)2-butynamide

Primary Target: EGFR/ErbB-2/ErbB-4
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      881001-19-0C₁₇H₁₁ClFN₅O•2.5H₂O
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, ATP-binding site-targeting alkynamidopyrimidine compound that acts as a potent and irreversible inhibitor of erbB activities (IC50 = 0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively). Inhibits EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells (IC50 = 2.5 and 24 nM, respectively).
      Catalogue Number324840
      Brand Family Calbiochem®
      SynonymsN-(4-((3-Chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)2-butynamide
      References
      ReferencesKlutchko, S.R., et al. 2006. J. Med. Chem. 49, 1475.
      Product Information
      CAS number881001-19-0
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₇H₁₁ClFN₅O•2.5H₂O
      Chemical formulaC₁₇H₁₁ClFN₅O•2.5H₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR/ErbB-2/ErbB-4
      Primary Target IC<sub>50</sub>0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively; 2.5 and 24 nM against EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      324840 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      324840

      References

      Reference overview
      Klutchko, S.R., et al. 2006. J. Med. Chem. 49, 1475.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-May-2010 JSW
      SynonymsN-(4-((3-Chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)2-butynamide
      DescriptionA cell-permeable, ATP-binding site-targeting alkynamidopyrimidine compound that acts as a potent and irreversible inhibitor of erbB activities (IC50 = 0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively). Inhibits EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells (IC50 = 2.5 and 24 nM, respectively).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number881001-19-0
      Chemical formulaC₁₇H₁₁ClFN₅O•2.5H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (4 mg/ml). Use fresh DMSO only.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKlutchko, S.R., et al. 2006. J. Med. Chem. 49, 1475.