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324483 Ebselen - CAS 60940-34-3 - Calbiochem

A cell-permeable, non-selective inhibitor of COX-1 and COX-2.

Ebselen - CAS 60940-34-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51

Primary Target: COX-1, COX-2
324483
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
60940-34-3C₁₃H₉NOSe

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324483-5MG
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      		 Glass bottle 5 mg
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      Description
      OverviewA cell-permeable, non-selective inhibitor of COX-1 and COX-2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent active against acute focal ischemic injury. Inhibits LPS-induced NF-κB nuclear translocation and LPS-induced phosphorylation of JNK.
      Catalogue Number324483
      Brand Family Calbiochem®
      Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
      References
      ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
      Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
      Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
      Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
      Wang, J.F., et al. 1992. Hepatology 5, 112.
      Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
      Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
      Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.
      Product Information
      CAS number60940-34-3
      ATP CompetitiveN
      FormLyophilized solid
      Hill FormulaC₁₃H₉NOSe
      Chemical formulaC₁₃H₉NOSe
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-1, COX-2
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      324483-5MG 04055977197242

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Ebselen - CAS 60940-34-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ebselen - CAS 60940-34-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      324483

      References

      Reference overview
      Shimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
      Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
      Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
      Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
      Wang, J.F., et al. 1992. Hepatology 5, 112.
      Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
      Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
      Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2008 RFH
      Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
      DescriptionNon-selective, cell-permeable, inhibitor of the cyclooxygenase activity of prostaglandin H synthase 1 and 2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent against acute focal ischemic injury.
      FormLyophilized solid
      CAS number60940-34-3
      Chemical formulaC₁₃H₉NOSe
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (5 mg/ml) or Ethanol
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
      Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
      Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
      Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
      Wang, J.F., et al. 1992. Hepatology 5, 112.
      Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
      Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
      Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.