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852044 FMOC-Asn(Trt)-OH

FMOC-Asn(Trt)-OH N-α-Fmoc-N-ß-trityl-L-asparagine Novabiochem®. CAS 132388-59-1, molar mass 596.69 g/mol.

FMOC-Asn(Trt)-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 132388-59-1 Molar Mass: 596.69 g/mol Hill Formula: C₃₈H₃₂N₂O₅
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
132388-59-1C₃₈H₃₂N₂O₅596.69 g/mol
Description
Catalogue Number852044
Replaces04-12-1089
Brand Family Novabiochem®
Alternate Names
  • N-α-Fmoc-N-β-trityl-L-asparagine
Background InformationFmoc-Asn(Trt)-OH has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Asn [1, 2]. Coupling can be performed by standard procedures. The trityl group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp residues. When Asn(Trt) is the N-terminal residue, the reaction time may need to be extended to ensure complete deprotection [3].

The product number for this product was previously 04-12-1089.

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References
Product Information
CAS number132388-59-1
Hill FormulaC₃₈H₃₂N₂O₅
Molar Mass596.69 g/mol
HS Code2924 29 99
Structure formula ImageStructure formula Image
Quality LevelMQ400
Applications
ApplicationFMOC-Asn(Trt)-OH N-α-Fmoc-N-ß-trityl-L-asparagine Novabiochem®. CAS 132388-59-1, molar mass 596.69 g/mol.
Biological Information
Physicochemical Information
Melting Point220 °C
pH value5.4 (H₂O, 23 °C)
Solubility<0.00005 g/l
Dimensions
Materials Information
Toxicological Information
LD 50 oralLD50 Rat > 2000 mg/kg
Safety Information according to GHS
Hazard Pictogram(s) Hazard Pictogram(s)
Hazard Statement(s)H411: Toxic to aquatic life with long lasting effects.
Precautionary Statement(s)P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/ container to an approved waste disposal plant.
Storage class10 - 13 Other liquids and solids
WGKWGK 2 obviously hazardous to water
Safety Information
Categories of dangerdangerous for the environment
Product Usage Statements
Storage and Shipping Information
StorageStore at -15°C to -25°C.
Packaging Information
Transport Information
Declaration (railroad and road) ADR, RIDUN 3077 , 9, III
Declaration (transport by air) IATA-DGRUN 3077 , 9, III
Declaration (transport by sea) IMDG-CodeUN 3077 , 9, III, Marine Pollutant: P
Supplemental Information
Specifications
Color (visual)white to off white
Appearance of substance (visual)powder
Color index (0,5 M in DMF)≤ 150 Hazen
Identity (IR)passes test
Enantiomeric purity≥ 99.7 % (a/a)
Purity (HPLC)≥ 99.0 % (a/a)
Fmoc-ß-Ala-OH (HPLC)≤ 0.1 % (a/a)
Fmoc-ß-Ala-Asn (Trt)-OH (HPLC)≤ 0.1 % (a/a)
Fmoc-Asn(Trt)-Asn(Trt)-OH (HPLC)≤ 0.1 % (a/a)
Fmoc-Asn-OH (HPLC)≤ 0.1 % (a/a)
Assay free amino acid (GC)≤ 0.2 %
Purity (TLC(011A))≥ 98 %
Purity (TLC(0811))≥ 98 %
Solubility (25 mmole in 50 ml DMF)clearly soluble
Assay (acidimetric)≥ 98.0 %
Water (K. F.)≤ 2.0 %
Ethyl acetate (HS-GC)≤ 0.5 %
Acetate (IC)≤ 0.05 %
For TLC-Systems see our General Catalog

Documentation

FMOC-Asn(Trt)-OH SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] P. Sieber, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium', R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 577.
  • [2] P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739.
  • [3] M. Friede, et al. (1992) Pept. Res., 5, 145.