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344550 FTI-276 - Calbiochem

A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC₅₀ = 500 pM).

FTI-276 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA

Primary Target: FTase in vitro
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₁H₂₇N₃O₃S₂
      Description
      OverviewA highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM.
      Catalogue Number344550
      Brand Family Calbiochem®
      SynonymsN-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA
      References
      ReferencesLantry, L.E., et al. 2000. Carcinogenesis 21, 113.
      Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
      Sun, J., et al. 1995. Cancer Res. 55, 4243.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₁H₂₇N₃O₃S₂
      Chemical formulaC₂₁H₂₇N₃O₃S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFTase in vitro
      Primary Target IC<sub>50</sub>500 pM against FTase in vitro
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      344550 0

      Documentation

      FTI-276 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      FTI-276 - Calbiochem Certificates of Analysis

      TitleLot Number
      344550

      References

      Reference overview
      Lantry, L.E., et al. 2000. Carcinogenesis 21, 113.
      Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
      Sun, J., et al. 1995. Cancer Res. 55, 4243.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2008 RFH
      SynonymsN-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA
      DescriptionA highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₂₇N₃O₃S₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C.
      Toxicity Standard Handling
      ReferencesLantry, L.E., et al. 2000. Carcinogenesis 21, 113.
      Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
      Sun, J., et al. 1995. Cancer Res. 55, 4243.