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344510 FTase Inhibitor I - Calbiochem

The FTase Inhibitor I controls the biological activity of FTase. This small molecule/inhibitor is primarily used for Cancer applications.

FTase Inhibitor I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[2(S)-[2(R)-Amino-3-mercaptopropylamino]-3-methylbutyl]-Phe-Met-OH, B581

Primary Target: FTase
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₂H₃₈N₄O₃S₂
      Description
      OverviewA potent, cell-permeable, selective, peptidomimetic inhibitor of farnesyltransferase (FTase) that is approximately 37-fold more active against FTase (IC50 = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC50 = 790 nM). Very resistant to proteolysis.
      Catalogue Number344510
      Brand Family Calbiochem®
      SynonymsN-[2(S)-[2(R)-Amino-3-mercaptopropylamino]-3-methylbutyl]-Phe-Met-OH, B581
      References
      ReferencesYamaguchi, M., et al. 2004. Stroke 35, 1750.
      Cox, A.D., et al. 1994. J. Biol. Chem. 269, 19203.
      Garcia, A.M., et al. 1993. J. Biol. Chem. 268, 18415.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₂H₃₈N₄O₃S₂
      Chemical formulaC₂₂H₃₈N₄O₃S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFTase
      Primary Target IC<sub>50</sub>21 nM against FTase in vitro
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      344510 0

      Documentation

      FTase Inhibitor I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      FTase Inhibitor I - Calbiochem Certificates of Analysis

      TitleLot Number
      344510

      References

      Reference overview
      Yamaguchi, M., et al. 2004. Stroke 35, 1750.
      Cox, A.D., et al. 1994. J. Biol. Chem. 269, 19203.
      Garcia, A.M., et al. 1993. J. Biol. Chem. 268, 18415.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2008 RFH
      SynonymsN-[2(S)-[2(R)-Amino-3-mercaptopropylamino]-3-methylbutyl]-Phe-Met-OH, B581
      DescriptionA potent, cell-permeable inhibitor of farnesyltransferase (FTase) that is about 37-fold more active against FTase (IC50 = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC50 = 790 nM). Very resistant to proteolysis.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₃₈N₄O₃S₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYamaguchi, M., et al. 2004. Stroke 35, 1750.
      Cox, A.D., et al. 1994. J. Biol. Chem. 269, 19203.
      Garcia, A.M., et al. 1993. J. Biol. Chem. 268, 18415.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors