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852102 Fmoc-Glu(biotinyl-PEG)-OH

Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
817169-73-6C₄₀H₅₅N₅O₁₀S797.98 g/mol
Description
Catalogue Number852102
Replaces04-12-1250
Brand Family Novabiochem®
Alternate Names
  • N-α-Fmoc-N-γ-(N-biotinyl-3-(2-(2-(3-aminopropyloxy)-ethoxy)-ethoxy)-propyl)-L-glutamine
Background InformationIn contrast to Fmoc-Lys(biotin)-OH, this novel biotin-labeled amino acid has excellent solubility in DMF and other solvents used in SPPS [1]. The PEG-spacer restricts hindrance between the peptide and avidin, leading to better biotin binding. Furthermore, the hydrophilic nature of the PEG minimizes non-specific interactions that can arise from the spacer group becoming buried in the hydrophobic pocket of proteins.

For recent applications, please see [2 - 4].

The product number for this product was previously 04-12-1250.

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References
Product Information
CAS number817169-73-6
Hill FormulaC₄₀H₅₅N₅O₁₀S
Molar Mass797.98 g/mol
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationFmoc-Glu(biotinyl-PEG)-OH Novabiochem®. CAS 817169-73-6, molar mass 797.98 g/mol.
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 2 obviously hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)passes test
Enantiomeric purity≥ 99.5 % (a/a)
Purity (TLC(CMA2))≥ 97 %
Assay (HPLC, area%)≥ 95.0 % (a/a)
Solubility (0,2 mmol in 1 ml DMF)clearly soluble
For TLC-Systems see our General Catalog

Documentation

Fmoc-Glu(biotinyl-PEG)-OH SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] B. Baumeister, et al. (2003) Biopolymers, 71, 339.
  • [2] X. Zhou et al., (2004) J. Am. Chem. Soc., 126, 15656.
  • [3] B. F. Gilmore, et al. (2006) Biochem. Biophys. Res. Commun,, 347, 373.
  • [4] C. T. Archer, et al. (2005) Mol. BioSyst., 1, 366.