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371706 GPR40 Agonist - CAS 885101-89-3 - Calbiochem

The GPR40 Agonist, also referenced under CAS 885101-89-3, controls the biological activity of GPR40. This small molecule/inhibitor is primarily used for Cell Signaling applications.

GPR40 Agonist - CAS 885101-89-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, FFA1 Agonist I, Free Fatty Acid Receptor 1 Agonist I

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371706
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
885101-89-3C₂₂H₂₁NO₃

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371706-10MG
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      Description
      OverviewA cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GPR40 (EC50 ~50 nM) with much reduced activity towards family members GPR120 (EC50 ~3.5 µM), GPR41/GPR43 (EC50 >50 µM), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca2+ mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit an in vivo half-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
      Catalogue Number371706
      Brand Family Calbiochem®
      Synonyms3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, FFA1 Agonist I, Free Fatty Acid Receptor 1 Agonist I
      References
      ReferencesMcKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
      Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.
      Product Information
      CAS number885101-89-3
      FormLight yellow solid
      Hill FormulaC₂₂H₂₁NO₃
      Chemical formulaC₂₂H₂₁NO₃
      HS Code2922 50 99
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      371706-10MG 04055977213898

      Documentation

      GPR40 Agonist - CAS 885101-89-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GPR40 Agonist - CAS 885101-89-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      371706

      References

      Reference overview
      McKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
      Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-January-2011 RFH
      Synonyms3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid, FFA1 Agonist I, Free Fatty Acid Receptor 1 Agonist I
      DescriptionA cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40 (EC50 ~50 nM) with much reduced activity towards family members GRP120 (EC50 ~3.5 µM), GRP41/GRP43 (EC50 >50 µM), as well as a panel of eight other fatty acid and prostaglandin receptors. Shown to induces GPR40-dependent Ca2+ mobilization in HEK-293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. Reported to exhibit an in vivo half-life of ≥5.3 hr. in rat (p.o. or i.v.) with a bioavailability of 65% and a clearance of 24.9 ml/min/kg.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number885101-89-3
      Chemical formulaC₂₂H₂₁NO₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (40 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMcKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584.
      Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.