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361541 GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Glycogen Synthase Kinase-3β Inhibitor II, 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole

Primary Target: Gsk-3β
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      478482-75-6C₁₄H₁₀IN₃OS
      Description
      Overview

      This product has been discontinued.



      A 2-thio-[1,3,4]-oxadiazole-pyridyl derivative that acts as a potent inhibitor of glycogen synthase kinase-3β (IC50 = 390 nM).
      Catalogue Number361541
      Brand Family Calbiochem®
      SynonymsGlycogen Synthase Kinase-3β Inhibitor II, 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole
      References
      ReferencesNaerum, L., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1525.
      Product Information
      CAS number478482-75-6
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₄H₁₀IN₃OS
      Chemical formulaC₁₄H₁₀IN₃OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGsk-3β
      Primary Target IC<sub>50</sub>390 nM against glycogen synthase kinase-3β
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      361541 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      361541

      References

      Reference overview
      Naerum, L., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1525.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-october-2007 JSW
      SynonymsGlycogen Synthase Kinase-3β Inhibitor II, 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole
      DescriptionA 2-thio-[1,3,4]-oxadiazole-pyridyl derivative that acts as a potent inhibitor of glycogen synthase kinase-3b (IC50 = 390 nM).

      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number478482-75-6
      Chemical formulaC₁₄H₁₀IN₃OS
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNaerum, L., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1525.