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361553 GSK-3β Inhibitor XI - CAS 626604-39-5 - Calbiochem

The GSK-3β Inhibitor XI, also referenced under CAS 626604-39-5, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione, 7AIPM

Primary Target: Gsk-3β
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361553
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
626604-39-5C₁₈H₁₅N₅O₃

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      		 Plastic ampoule 1 mg
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      Description
      OverviewA cell-permeable azaindolylmaleimide compound that acts as a potent, specific, and ATP-competitive inhibitor of GSK-3β (Ki = 25 nM) and minimally inhibits a panel of 79 commonly studied protein kinases, including several PKC isozymes. Shown to increase intracellular glycogen synthase activity in HEK293 cells with an EC50 of 32 nM and demonstrate metabolic stability in human liver microsomes (HLM; t1/2 > 100 min).
      Catalogue Number361553
      Brand Family Calbiochem®
      Synonyms3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione, 7AIPM
      References
      ReferencesJustman, Q.A., et al. 2009. Science 324, 509.
      O'Neill, D.J., et al. 2004. Bioorg. Med. Chem. 12, 3167.
      Product Information
      CAS number626604-39-5
      ATP CompetitiveY
      FormOrange red solid
      Hill FormulaC₁₈H₁₅N₅O₃
      Chemical formulaC₁₈H₁₅N₅O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGsk-3β
      Primary Target K<sub>i</sub>25 nM against GSK-3β
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      361553-1MG 04055977214116

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      GSK-3β Inhibitor XI - CAS 626604-39-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GSK-3β Inhibitor XI - CAS 626604-39-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      361553

      References

      Reference overview
      Justman, Q.A., et al. 2009. Science 324, 509.
      O'Neill, D.J., et al. 2004. Bioorg. Med. Chem. 12, 3167.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2009 RFH
      Synonyms3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione, 7AIPM
      DescriptionA cell-permeable, potent, specific, and ATP-competitive inhibitor of GSK-3β (Ki = 25 nM) that exhibits minimal inhibition against a panel of 79 commonly studied protein kinases, including several PKC isozymes. Shown to increase intracellular glycogen synthase activity in HEK293 cells (EC50 = 32 nM) and demonstrate metabolic stability in human liver microsomes (HLM; t1/2 >100 min).
      FormOrange red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number626604-39-5
      Chemical formulaC₁₈H₁₅N₅O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesJustman, Q.A., et al. 2009. Science 324, 509.
      O'Neill, D.J., et al. 2004. Bioorg. Med. Chem. 12, 3167.