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346006 Glucagon-Like Peptide 1 Receptor Agonist - CAS 281209-71-0 - Calbiochem

Glucagon-Like Peptide 1 Receptor Agonist, CAS 281209-71-0, modulates GLP-1 binding & induces cAMP production in BHK membranes. Potentiates glucose-dependent insulin release in WT pancreatic islets.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GLP-1R Agonist, 6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      281209-71-0C₁₃H₁₅Cl₂N₃O₂S
      Description
      Overview

      This product has been discontinued.



      A nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50 = 101 nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin.
      Catalogue Number346006
      Brand Family Calbiochem®
      SynonymsGLP-1R Agonist, 6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline
      References
      ReferencesKnudsen, L. B., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 937.
      Product Information
      CAS number281209-71-0
      FormYellow solid
      Hill FormulaC₁₃H₁₅Cl₂N₃O₂S
      Chemical formulaC₁₃H₁₅Cl₂N₃O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationGlucagon-Like Peptide 1 Receptor Agonist, CAS 281209-71-0, modulates GLP-1 binding & induces cAMP production in BHK membranes. Potentiates glucose-dependent insulin release in WT pancreatic islets.
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      346006 0

      Documentation

      Glucagon-Like Peptide 1 Receptor Agonist - CAS 281209-71-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      346006

      References

      Reference overview
      Knudsen, L. B., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 937.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      SynonymsGLP-1R Agonist, 6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline
      DescriptionA nonpeptidic quinoxaline compound that acts as a GLP-1R agonist and an allosteric modulator of GLP-1 binding. Shown to induce GLP-1R-mediated cAMP production in BHK plasma membrane preparations (EC50 = 101 nM) and potentiate glucose-dependent insulin release in pancreatic islets derived from wild-type, but not GLP-1R -/-, mice. Unlike GLP-1, its biological activity is not inhibited by orthosteric antagonists such as Exendin.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number281209-71-0
      Chemical formulaC₁₃H₁₅Cl₂N₃O₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (20 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesKnudsen, L. B., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 937.