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851006 HBTU

HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®. CAS 94790-37-1, chemical formula C₁₁H₁₆N₅O*F₆P.

HBTU MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 94790-37-1 EC Number: 423-020-5 Molar Mass: 379.25 g/mol Chemical Formula: C₁₁H₁₆N₅O*F₆P Hill Formula: C₁₁H₁₆N₅O*F₆P
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851006
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Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
94790-37-1423-020-5C₁₁H₁₆N₅O*F₆PC₁₁H₁₆N₅O*F₆P379.25 g/mol
Description
Catalogue Number851006
Replaces01-62-0010
Brand Family Novabiochem®
DescriptionHBTU
Alternate Names
  • 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate
Background InformationTBTU and HBTU are two of the most popular in situ activation reagents used in solid phase and solution phase peptide synthesis [1-9]. These reagents offer reactivity similar to symmetrical anhydrides and BOP [1]. Couplings proceed smoothly and rates can even be enhanced by the addition of HOBt [2, 4, 5, 6]. In addition to having high reactivity, TBTU and HBTU have also been shown to limit enantiomerization during fragment condensation and during DMAP catalyzed esterification of arginine derivatives [3]. Comparative experiments between HBTU and TBTU have shown that the counter ion has no influence on coupling rates or levels of enantiomerization [1].

The product number for this product was previously 01-62-0010.

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References
Product Information
CAS number94790-37-1
EC number423-020-5
Hill FormulaC₁₁H₁₆N₅O*F₆P
Chemical formulaC₁₁H₁₆N₅O*F₆P
Molar Mass379.25 g/mol
HS Code2933 99 99
Structure formula ImageStructure formula Image
Quality LevelMQ300
Applications
ApplicationHBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®. CAS 94790-37-1, chemical formula C₁₁H₁₆N₅O*F₆P.
Biological Information
Physicochemical Information
Melting Point250 °C
pH value4.1 (1.6 g/l, H₂O)
Solubility1.6 g/l
Dimensions
Materials Information
Toxicological Information
LD 50 oralLD50 Rat > 2000 mg/kg
Safety Information according to GHS
Hazard Pictogram(s) Hazard Pictogram(s)
Hazard Statement(s)H317: May cause an allergic skin reaction.
Precautionary Statement(s)P261: Avoid breathing dust.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves.
P302 + P352: IF ON SKIN: Wash with plenty of water.
P333 + P313: If skin irritation or rash occurs: Get medical advice/ attention.
P362 + P364: Take off contaminated clothing and wash it before reuse.
Signal WordWarning
Storage class10 - 13 Other liquids and solids
WGKWGK 3 highly hazardous to water
Safety Information
Categories of dangerirritant
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Declaration (railroad and road) ADR, RIDKein Gefahrgut
Declaration (transport by air) IATA-DGRNo Dangerous Good
Declaration (transport by sea) IMDG-CodeNo Dangerous Good
Supplemental Information
Specifications
Colour (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)passes test
Assay (HPLC, area%)≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF)clearly soluble

Documentation

HBTU SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] R. Knorr, et al. (1989) Tetrahedron Lett., 30, 1927.
  • [2] M. S. Bernatowicz, et al. (1989) Tetrahedron Lett., 30, 4645.
  • [3] D. Ambrosius, et al. (1989) Biol. Chem. Hoppe-Seyler, 370, 217.
  • [4] C. G. Fields, et al. (1991) Pept. Res., 4, 95.
  • [5] A. G. Beck-Sickinger, et al. (1991) Pept. Res., 4, 88.
  • [6] G. E. Reid, et al. (1992) Anal. Biochem., 200, 301.
  • [7] G. B. Fields, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium', R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
  • [8] P. A. Baybayan, et al. in 'Peptides, Chemistry & Biology, Proc. 12th American Peptide Symposium', J. A. Smith & J. E. Rivier (Eds), ESCOM, Leiden, 1992, pp. 566.
  • [9] J. J. Dudash, et al. (1993) Synth. Commun., 23, 349.