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851012 HCTU

HCTU O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®. CAS 330645-87-9, molar mass 413.69 g/mol.

HCTU MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: HCTU

CAS #: 330645-87-9 Molar Mass: 413.69 g/mol Hill Formula: C₁₁H₁₅ClF₆N₅OP
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851012
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
330645-87-9C₁₁H₁₅ClF₆N₅OP413.69 g/mol
Description
Catalogue Number851012
Replaces01-62-0038
Brand Family Novabiochem®
SynonymsHCTU
Alternate Names
  • 2-(6-Chloro-1-H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate
Background InformationHCTU [1] is a novel aminium-based coupling reagent, analogous to HBTU, which in comparative studies was found to give superiort results to TBTU in the synthesis of difficult peptides [2], in hindered couplings [3], and cyclizations [4].

The product number for this product was previously 01-62-0038.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
References
Product Information
CAS number330645-87-9
Hill FormulaC₁₁H₁₅ClF₆N₅OP
Molar Mass413.69 g/mol
HS Code2933 99 99
Structure formula ImageStructure formula Image
Quality LevelMQ300
Applications
ApplicationHCTU O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®. CAS 330645-87-9, molar mass 413.69 g/mol.
Biological Information
Physicochemical Information
Melting Point>185 °C
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Hazard Pictogram(s) Hazard Pictogram(s)
Hazard Statement(s)H317: May cause an allergic skin reaction.
Precautionary Statement(s)P261: Avoid breathing dust.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves.
P302 + P352: IF ON SKIN: Wash with plenty of water.
P333 + P313: If skin irritation or rash occurs: Get medical advice/ attention.
P362 + P364: Take off contaminated clothing and wash it before reuse.
Signal WordWarning
Storage class10 - 13 Other liquids and solids
WGKWGK 3 highly hazardous to water
Disposal3
Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
Safety Information
Categories of dangerhighly flammable
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Declaration (railroad and road) ADR, RIDKein Gefahrgut
Declaration (transport by air) IATA-DGRNo Dangerous Good
Declaration (transport by sea) IMDG-CodeNo Dangerous Good
Supplemental Information
Specifications
Colour (visual)white to off white
Appearance of substance (visual)powder
Identity (IR)passes test
Assay (HPLC, area%)≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF)clearly soluble
Water (K. F.)≤ 0.50 %
For TLC-Systems see our General Catalog

Documentation

HCTU SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] O. Marder, et al. (2002) Chimica Oggi, 37.
  • [2] G. Sabatino, et al. in 'Peptides 2002, Proceedings of the 27th European Peptide Symposium', E. Benedetti & C. Pedone (Eds), Naples, Edizioni Ziino, 2002, pp. 272.
  • [3] M. Gude & S. Barthélémy in 'Peptides 2002, Proceedings of the 27th European Peptide Symposium', E. Benedetti & C. Pedone (Eds), Naples, Edizioni Ziino, 2002, pp. 122.
  • [4] G. Sabatino, et al. in 'Peptide Revolution: Genomics, Proteomics & Therapeutics, , Proc. 18th American Peptide Symposium', M. Chrev & T. K. Sawyer (Eds), Cardiff, American Peptide Society, 2003, pp. 49.