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382110 Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem

382110
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₂₀H₁₆Br₂O₃932749-62-7

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382110-10MG
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      Description
      OverviewA cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 ≤ 40 µM) and induce chromatin condensation in HeLa cells.
      Catalogue Number382110
      Brand Family Calbiochem®
      Synonyms2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I
      References
      ReferencesCosti, R., et al. 2007. J. Med. Chem. 50, 1973.
      Product Information
      CAS number932749-62-7
      FormYellow solid
      Hill FormulaC₂₀H₁₆Br₂O₃
      Chemical formulaC₂₀H₁₆Br₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      382110

      References

      Reference overview
      Costi, R., et al. 2007. J. Med. Chem. 50, 1973.

      Brochure

      Title
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      Synonyms2,6-bis-(3-Bromo-4-hydroxybenzylidene)cyclohexanone, HAT Inhibitor II, p300/CBP Inhibitor II, GCN5 Inhibitor I
      DescriptionA cell-permeable bis-arylidene cyclohexanone compound that acts as a p300/CBP-selective histone acetyltransferase inhibitor (IC50 = 5 µM), while it affects GCN5 and PCAF only at much higher concentrations (30% and 0% inhibition, respectively, at 5 µM inhibitor concentration). Shown to decrease histone H3 acetylation (IC50 ≤40 µM) and induce chromatin condensation in HeLa cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number932749-62-7
      Chemical formulaC₂₀H₁₆Br₂O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml) or Ethanol (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month.
      Toxicity Standard Handling
      ReferencesCosti, R., et al. 2007. J. Med. Chem. 50, 1973.