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855117 Hydroxylamine Wang resin

Novabiochem®

Hydroxylamine Wang resin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 65307-53-1
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855117
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Overview

Replacement Information

Key Spec Table

CAS #
65307-53-1
Description
Catalogue Number855117
Replaces01-64-0454
Brand Family Novabiochem®
Alternate Names
  • Amino-oxy Wang resin
Background InformationAn excellent support for the preparation of peptide hydroxamic acids [1]. Acylation of the resin has been carried out using TBTU/DIPEA activation [1]. Alkylation of the resin-bound nitrogen has been effected using TMOF/DCE/AcOH for imine formation, followed by reduction with BH3-pyridine [2], by base-mediated alkylation of the N-Boc-protected hydroxylamine, followed by Boc removal with 20% TFA in DCM [3], or by Michael-addition [4]. Cleavage of hydroxamates from the resin has been effected with TFA/DCM/water (70:28:2) [1] or TFA/DCM (1:1) [2].

Hydroxylamine Wang resin has also been utilized to prepare tertiary amines by base-mediated elimination of the quaternized polymer-bound hydroxylamine [3, 5].

The product number for this product was previously 01-64-0454.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
References
Product Information
CAS number65307-53-1
HS Code3903 90 90
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 1 slightly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)white to yellow to beige
Appearance of substance (visual)beads
Loading (determined by elemental analysis of nitrogen)1.5 - 2.5 mmol/g
Swelling Volume (in DMF)lot specific result
The polymer matrix is copoly (styrene - 1% DVB), 100 - 200 mesh.

Documentation

Hydroxylamine Wang resin SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] C. D. Floyd, et al. (1996) Tetrahedron Lett., 37, 8045.
  • [2] D. E. Robinson & M. W. Holladay (2000) Org. Lett., 2, 2777.
  • [3] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6635.
  • [4] A. Volonterio, et al. (2002) Eur. J. Org. Chem., 428.
  • [5] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6639.