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855068 Hydroxymethyl polystyrene (100-200 mesh), 1% DVB

Novabiochem®

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 9003-70-7
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855068
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Overview

Replacement Information

Key Spec Table

CAS #
9003-70-7
Description
Catalogue Number855068
Replaces01-64-0110
Brand Family Novabiochem®
Alternate Names
  • Polystyrene-CH2OH (100-200 mesh)
Background InformationThis resin is ideal for the solid phase immobilization of carboxylic acids. Less cross-linking is observed than with Merrifield resin during the attachment of diacids [1]. Reaction with a suitable phosgene equivalent converts this resin to a support suitable for the immobilization of amines [2].

Release of carboxylic acids from this support is normally effected by treatment of the resin with HF or TFMSA, or by hydrogenolysis [3]. Alcohols can be liberated by reduction with DIBAL [4] or LiBH4 [5]. Methyl esters can be produced by transesterification with MeONa [6] or Ti(OEt)4/C2H5CO2Me [7]. Carboxamides are also accessible via Lewis acid catalyzed aminolysis [8].

The product number for this product was previously 01-64-0110.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
References
Product Information
CAS number9003-70-7
HS Code3903 90 90
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 1 slightly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore below +30°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)white to yellow to beige
Appearance of substance (visual)beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin)0.60 - 1.60 mmol/g
Swelling Volume (in DMF)lot specific result
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

Documentation

Hydroxymethyl polystyrene (100-200 mesh), 1% DVB SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] J. M. Goldwasser, et al. (1978) Can. J. Chem., 56, 1562.
  • [2] D. J. Burdick, et al. (1993) Tetrahedron Lett., 34, 2589.
  • [3] J. M. Schlatter, et al. (1977) Tetrahedron Lett., 2851.
  • [4] M. J. Kurth, et al. (1994) J. Org. Chem., 59, 5862.
  • [5] J. M. Stewart & J. D. Young in 'Solid Phase Peptide Synthesis, 2nd Ed.', Rockford, Illinois, Pierce Chemical Company, 1984, pp. 92.
  • [6] R. Frenette, et al. (1994) Tetrahedron Lett., 35, 9177.
  • [7] L. T. Tietze & A. Steinmetz (1996) Angew. Chem. Int. Ed. Engl., 35, 651.
  • [8] D. R. Barn, et al. (1996) Tetrahedron Lett., 37, 3213.