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440209 LY 295427

LY 295427 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (3α,4α,5α)-4-(2-Propenyl)cholestan-3-ol

440209
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      We apologize for the inconvenience, but we do not currently have an alternative product.





      A novel hypocholesterolemic agent that reduces plasma cholesterol levels in animals by increasing the expression of hepatic low-density lipoprotein (LDL) receptors. However, recent studies have attributed the hypocholesterolemic activity of LY 295427 to its ability to reverse oxysterol-mediated suppression of sterol regulatory element-binding protein (SREBP) processing. Micromolar concentrations of this sterol restored the metabolism of LDL in oxysterol-treated cultured cells and inhibited the stimulation of cholesteryl ester synthesis mediated by oxysterols.
      Catalogue Number440209
      Brand Family Calbiochem®
      Synonyms(3α,4α,5α)-4-(2-Propenyl)cholestan-3-ol
      References
      ReferencesJanowski, B.A. 2002. Proc. Natl. Acad. Sci. 99, 12675. Janowski, B.A., et al. 2001. J. Biol. Chem. 276, 45408. Lin, H.S., et al. 1999. Steroids 64, 217. Bowling, N., et al. 1996. J. Lipid Res. 37, 2586. Lin, H.S., et al. 1995. J. Med. Chem. 38, 277.
      Product Information
      FormWhite solid
      Hill FormulaC₃₀H₅₂O
      Chemical formulaC₃₀H₅₂O
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      440209 0

      Documentation

      LY 295427 Certificates of Analysis

      TitleLot Number
      440209

      References

      Reference overview
      Janowski, B.A. 2002. Proc. Natl. Acad. Sci. 99, 12675. Janowski, B.A., et al. 2001. J. Biol. Chem. 276, 45408. Lin, H.S., et al. 1999. Steroids 64, 217. Bowling, N., et al. 1996. J. Lipid Res. 37, 2586. Lin, H.S., et al. 1995. J. Med. Chem. 38, 277.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      Synonyms(3α,4α,5α)-4-(2-Propenyl)cholestan-3-ol
      DescriptionA novel hypocholesterolemic agent that reduces plasma cholesterol levels in animals by increasing the expression of hepatic low-density lipoprotein (LDL) receptors. Also reported to reverse the suppression of sterol regulatory element-binding protein (SREBP) processing mediated by several oxysterols and cholesterol derivative in CHO-7 cells and in human fibroblasts. At micromolar levels, it induces the metabolism of LDL in oxysterol-treated cells and inhibits the stimulation of cholesteryl ester synthesis mediated by oxysterols.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₅₂O
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityEthanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesJanowski, B.A. 2002. Proc. Natl. Acad. Sci. 99, 12675. Janowski, B.A., et al. 2001. J. Biol. Chem. 276, 45408. Lin, H.S., et al. 1999. Steroids 64, 217. Bowling, N., et al. 1996. J. Lipid Res. 37, 2586. Lin, H.S., et al. 1995. J. Med. Chem. 38, 277.