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440203 LY 303511 - CAS 154447-38-8 - Calbiochem

A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002.

LY 303511 - CAS 154447-38-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V

Primary Target: Negative control for the PI 3-kinase inhibitor LY 294002
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      154447-38-8C₁₉H₁₈N₂O₂
      Description
      OverviewA cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC50 ~10 µM).
      Catalogue Number440203
      Brand Family Calbiochem®
      Synonyms2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V
      References
      ReferencesDittman, et al. 2014. ACS Chem Biol. 9, 495.
      Ding, J., et al. 1995. J. Biol. Chem. 270, 11684.
      Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
      Product Information
      CAS number154447-38-8
      ATP CompetitiveN
      FormAmber solid
      Hill FormulaC₁₉H₁₈N₂O₂
      Chemical formulaC₁₉H₁₈N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNegative control for the PI 3-kinase inhibitor LY 294002
      Primary Target IC<sub>50</sub>Does not inhibit PI 3-kinase even at a concentration of 100 µM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      440203 0

      Documentation

      LY 303511 - CAS 154447-38-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      LY 303511 - CAS 154447-38-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      440203

      References

      Reference overview
      Dittman, et al. 2014. ACS Chem Biol. 9, 495.
      Ding, J., et al. 1995. J. Biol. Chem. 270, 11684.
      Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.

      Posters

      Title
      Human Kinome & InhibitorSelect™ Libraries
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2007 JSW
      Synonyms2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V
      DescriptionA cell-permeable, negative control for the phosphatidylinositol-3-kinase (PI-3 kinase) inhibitor, LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not affect PI-3 kinase activity even at concentrations ≥100 µM.
      FormAmber solid
      CAS number154447-38-8
      Chemical formulaC₁₉H₁₈N₂O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesDittman, et al. 2014. ACS Chem Biol. 9, 495.
      Ding, J., et al. 1995. J. Biol. Chem. 270, 11684.
      Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.