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428206 Lck Inhibitor II - CAS 918870-43-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)pyrimidin-4-ylamino)-4-methylphenol

428206
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      918870-43-6C₂₄H₂₆N₆O₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor (IC50 = 3 nM; [ATP] = 10 µM). Shown to block IL-2 release in Jurkat E6-1 T cell line (IC50 = 54 nM) stimulated by CD3 cross-linking and PMA.
      Catalogue Number428206
      Brand Family Calbiochem®
      Synonyms3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)pyrimidin-4-ylamino)-4-methylphenol
      References
      ReferencesSabat, M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 5973.
      Product Information
      CAS number918870-43-6
      FormLight yellow solid
      Hill FormulaC₂₄H₂₆N₆O₃
      Chemical formulaC₂₄H₂₆N₆O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      428206 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Lck Inhibitor II - CAS 918870-43-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Lck Inhibitor II - CAS 918870-43-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      428206

      References

      Reference overview
      Sabat, M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 5973.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)pyrimidin-4-ylamino)-4-methylphenol
      DescriptionA cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor (IC50 = 3 nM; [ATP] = 10 µM). Shown to block IL-2 release in Jurkat E6-1 T cell line (IC50 = 54 nM) stimulated by CD3 cross-linking and PMA.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number918870-43-6
      Chemical formulaC₂₄H₂₆N₆O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (35 mg/ml) or Ethanol (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSabat, M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 5973.