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454880 MARCKS PSD-Derived Peptide, PKC Substrate

MARCKS PSD-Derived Peptide, PKC Substrate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: KKRFSFKKSFKL

454880
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      Please refer to our complete listing of PKC substrates for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.







      Peptide sequence (amino acids 154-165) from myristoylated alanine-rich C-kinase substrate (MARCKS) protein phosphorylation site domain (PSD). Contains the first two of the four serine residues in the PSD. Phosphorylated by protein kinase C (including PKCα and β, naturally-occurring PKC δ, ε, and θ, as well as atypical PKC ξ) at Ser5 and Ser9, even though atypical PKCs do not utilize intact MARCKS as a substrate. Poor substrate for CaM kinase I, CaM kinase II, CaM kinase III, protein kinase A, and protein kinase G.
      Catalogue Number454880
      Brand Family Calbiochem®
      SynonymsKKRFSFKKSFKL
      References
      ReferencesUberall, F., et al. 1997. J. Biol. Chem. 272, 4072.
      Herget, T., et al. 1995. Eur. J. Biochem. 233, 448.
      Fujise, A., et al. 1994. J. Biol. Chem. 269, 31642.
      Blackshear, P.J. 1993. J. Biol. Chem. 268, 1501.
      Amess, B., et al. 1992. FEBS Lett. 297, 285.
      Graff, J.M., et al. 1991. J. Biol. Chem. 266, 14390.
      Product Information
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₇₅H₁₂₃N₂₁O₁₄
      Chemical formulaC₇₅H₁₂₃N₂₁O₁₄
      Sold on the basis of peptide contentY
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide ContentY
      Peptide SequenceH-Lys-Lys-Arg-Phe-Ser-Phe-Lys-Lys-Ser-Phe-Lys-Leu-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      454880 0

      Documentation

      MARCKS PSD-Derived Peptide, PKC Substrate Certificates of Analysis

      TitleLot Number
      454880

      References

      Reference overview
      Uberall, F., et al. 1997. J. Biol. Chem. 272, 4072.
      Herget, T., et al. 1995. Eur. J. Biochem. 233, 448.
      Fujise, A., et al. 1994. J. Biol. Chem. 269, 31642.
      Blackshear, P.J. 1993. J. Biol. Chem. 268, 1501.
      Amess, B., et al. 1992. FEBS Lett. 297, 285.
      Graff, J.M., et al. 1991. J. Biol. Chem. 266, 14390.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2008 RFH
      SynonymsKKRFSFKKSFKL
      DescriptionPeptide sequence (residues 154-165) from myristoylated alanine-rich C-kinase substrate (MARCKS) protein phosphorylation site domain (psd). Contains the first two of the four serine residues in the psd. Phosphorylated by protein kinase C (including cPKC α and β, nPKC δ, ε, and θ, as well as aPKC ξ) at Ser-5 and 9, even though aPKCs do not utilize intact MARCKS as a substrate. Poor substrate for CaM kinase I, CaM kinase II, CaM kinase III, protein kinase A, and protein kinase G.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₇₅H₁₂₃N₂₁O₁₄
      Peptide SequenceH-Lys-Lys-Arg-Phe-Ser-Phe-Lys-Lys-Ser-Phe-Lys-Leu-OH
      Purity≥95% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesUberall, F., et al. 1997. J. Biol. Chem. 272, 4072.
      Herget, T., et al. 1995. Eur. J. Biochem. 233, 448.
      Fujise, A., et al. 1994. J. Biol. Chem. 269, 31642.
      Blackshear, P.J. 1993. J. Biol. Chem. 268, 1501.
      Amess, B., et al. 1992. FEBS Lett. 297, 285.
      Graff, J.M., et al. 1991. J. Biol. Chem. 266, 14390.