444143 Sigma-AldrichMDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem
The MDM2 Antagonist, Nutlin-3, Racemic, also referenced under CAS 548472-68-0, controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Cancer applications.
More>> The MDM2 Antagonist, Nutlin-3, Racemic, also referenced under CAS 548472-68-0, controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Cancer applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: MDM2 Inhibitor IV
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 548472-68-0 | C₃₀H₃₀Cl₂N₄O₄ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 444143-1MG |
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Plastic ampoule | 1 mg |
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| Description | |
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| Overview | A cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available. |
| Catalogue Number | 444143 |
| Brand Family | Calbiochem® |
| Synonyms | MDM2 Inhibitor IV |
| References | |
|---|---|
| References | Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015. Vassilev, L.T., et al. 2004. Science 303, 844. |
| Product Information | |
|---|---|
| CAS number | 548472-68-0 |
| ATP Competitive | N |
| Form | Solid |
| Hill Formula | C₃₀H₃₀Cl₂N₄O₄ |
| Chemical formula | C₃₀H₃₀Cl₂N₄O₄ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | MDM2 |
| Primary Target IC<sub>50</sub> | 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b |
| Purity | ≥98% by TLC and HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 444143-1MG | 07790788050337 |
Documentation
MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem SDS
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MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 444143 |
References
| Reference overview |
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| Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015. Vassilev, L.T., et al. 2004. Science 303, 844. |
Brochure
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| Interactive Pathway Calendar |