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444938 MEK Inhibitor II - CAS 623163-52-0 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone

Primary Target: MEK1
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      623163-52-0C₁₄H₈NO₄Cl
      Description
      Overview

      This product has been discontinued.



      A cell-permeable 1,4-naphthoquinone compound that acts as potent and selective inhibitor of MEK (IC50 = 0.38 µM for MEK1). It shows little effect on PKC and PKA, and inhibits Raf1 and ERK1 only at much higher concentrations (IC50 = 34.5 and 82.9 µM, respectively).
      Catalogue Number444938
      Brand Family Calbiochem®
      Synonyms2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone
      References
      ReferencesBakare, O., et al. 2003. Bioorg. Med. Chem. 11, 3165.
      Product Information
      CAS number623163-52-0
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₄H₈NO₄Cl
      Chemical formulaC₁₄H₈NO₄Cl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMEK1
      Primary Target IC<sub>50</sub>0.38 µM for MEK1
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      444938 0

      Documentation

      MEK Inhibitor II - CAS 623163-52-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MEK Inhibitor II - CAS 623163-52-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      444938

      References

      Reference overview
      Bakare, O., et al. 2003. Bioorg. Med. Chem. 11, 3165.

      Brochure

      Title
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-December-2008 RFH
      Synonyms2-Chloro-3-(N-succinimidyl)-1,4-naphthoquinone
      DescriptionA cell-permeable, potent, and selective inhibitor of MEK (IC50 = 380 nM for MEK1). Exhibits negligible inhibitory effects on protein kinase C (PKC) and protein kinase A (PKA). Inhibits Raf1 and ERK1 only at much higher concentrations (IC50 = 34.5 µM and 82.9 µM, respectively).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number623163-52-0
      Chemical formulaC₁₄H₈NO₄Cl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesBakare, O., et al. 2003. Bioorg. Med. Chem. 11, 3165.