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444247 MMP Inhibitor II - CAS 203915-59-7 - Calbiochem

The MMP Inhibitor II, also referenced under CAS 203915-59-7, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide

Primary Target: MMP-1
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      203915-59-7C₂₁H₂₇N₃O₈S₂
      Description
      OverviewA potent, reversible, broad-range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).
      Catalogue Number444247
      Brand Family Calbiochem®
      SynonymsN-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide
      References
      ReferencesPikul, S., et al. 1998. J. Med. Chem. 41, 3568.
      Product Information
      CAS number203915-59-7
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₁H₂₇N₃O₈S₂
      Chemical formulaC₂₁H₂₇N₃O₈S₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-1
      Primary Target IC<sub>50</sub>24 nM, 18.4 nM, 30 nM, 2.7 nM, against MMP-1, MMP-3, MMp-7, and MMP-9, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      444247 0

      Documentation

      MMP Inhibitor II - CAS 203915-59-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MMP Inhibitor II - CAS 203915-59-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      444247

      References

      Reference overview
      Pikul, S., et al. 1998. J. Med. Chem. 41, 3568.

      Citations

      Title
    • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      SynonymsN-Hydroxy-1,3-di-(4-methoxybenzenesulphonyl)-5,5-dimethyl-[1,3]-piperazine-2-carboxamide
      DescriptionA potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number203915-59-7
      Chemical formulaC₂₁H₂₇N₃O₈S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml). Requires vigorous vortexing for 60 seconds to completely solubilize the product.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesPikul, S., et al. 1998. J. Med. Chem. 41, 3568.
      Citation
    • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
      		•