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851011 MSNT

MSNT Novabiochem®. CAS 74257-00-4, molar mass 296.31 g/mol.

MSNT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 74257-00-4 Molar Mass: 296.31 g/mol Hill Formula: C₁₁H₁₂N₄O₄S
851011
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
74257-00-4C₁₁H₁₂N₄O₄S296.31 g/mol
Description
Catalogue Number851011
Replaces01-62-0021
Brand Family Novabiochem®
Alternate Names
  • 1-(Mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole
Background InformationThis versatile reagent was originally used as a coupling reagent in phosphotriester oligonucleotide synthesis [1-3]. In recent years, it has been increasingly used for the esterification of Fmoc-amino acids onto solid phase synthesis supports [4-12]. It has proved particularly effective in difficult cases involving unreactive linkers [8, 9] or enantiomerization prone amino acids [7]. In an investigation [6] into ester formation, in which the alcohol or carboxylic acid component was immobilized on a solid support, MSNT was found to give the best results of all the reagents tested (DCC, DCC/HOBt, DCC/DMAP, Ph3P/DEAD).

The product number for this product was previously 01-62-0021.

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References
Product Information
CAS number74257-00-4
Hill FormulaC₁₁H₁₂N₄O₄S
Molar Mass296.31 g/mol
HS Code2935 90 90
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationMSNT Novabiochem®. CAS 74257-00-4, molar mass 296.31 g/mol.
Biological Information
Physicochemical Information
Melting Point132 - 134 °C
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 3 highly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at -15°C to -25°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Colour (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)passes test
Assay (HPLC, area%)≥ 95.0 % (a/a)

Documentation

MSNT SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] C. B. Reese, et al. (1978) Tetrahedron Lett., 19, 2727.
  • [2] N. Balgobin, et al. (1981) Tetrahedron Lett., 22, 1915.
  • [3] W. Bannwarth (1987) Chimia, 41, 302.
  • [4] R. Frank, et al. (1988) Tetrahedron, 44, 6031.
  • [5] B. Blankemeyer-Menge, et al. (1990) Tetrahedron Lett., 31, 1701.
  • [6] J. Nielsen (1996) Tetrahedron Lett., 37, 8439.
  • [7] E. Harth-Fritschy & D. Cantacuzène (1997) J. Peptide Res., 50, 415.
  • [8] M. Renil, et al. (1998) J. Peptide Sci., 4, 195.
  • [9] M. Meldal, et al. (1998) J. Peptide Sci., 4, 83.
  • [10] A. Graven, et al. (2000) J. Chem. Soc., Perkin Trans. 1, 955.
  • [11] K. S. Kumar, et al. (2001) J. Peptide Res., 57, 140.
  • [12] H. Emtenäs, et al. (2002) J. Comb. Chem., 4, 630.