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505208 Methyllycaconitine Citrate - CAS 21019-30-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AChR Receptor Antagonist, Methyllycaconitine Citrate, alpha7beta2 recptor Antagonist, Methyllycaconitine Citrate, Methyllycaconitine; α7-Nicotinic Receptor Antagonist, Methyllycaconitine Citrate, Neuronal Nicotinic Receptor Antagonist, Methyllycaconitine Citrate

Primary Target: a7 AchR
505208
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      21019-30-7C₃₇H₅₀N₂O₁₀&;bull;C₆H₈O₇
      Description
      OverviewA potent antagonist highly selective for AChRs with α7 subunit (Ki = 1.4 nM for α7 subunit and > 40 nM for α4β2 and α6β2 receptors). Frequently used in assessing the functional roles of AChRs with α7 subunit in brain functions and disorders (i.e. inflammatory and chronic neuropathic pain and parkinsonian neurodegeneration).
      Catalogue Number505208
      Brand Family Calbiochem®
      SynonymsAChR Receptor Antagonist, Methyllycaconitine Citrate, alpha7beta2 recptor Antagonist, Methyllycaconitine Citrate, Methyllycaconitine; α7-Nicotinic Receptor Antagonist, Methyllycaconitine Citrate, Neuronal Nicotinic Receptor Antagonist, Methyllycaconitine Citrate
      References
      ReferencesSuzuki, S., et al. 2013. J. Neurosci. Res. 91, 462.
      Freitas, K., et al. 2013. Neuropharmacol. 65, 156.
      Sheeja, N., et al. 2012. Hippocampus. 22, 335.
      Xiong, Y., et al. 2010. Pharmacol. Biochem. & Beha. 95, 192.
      Whiteaker, P., et al. 1999. Eur. J. Neurosci. 11, 96.
      Product Information
      CAS number21019-30-7
      FormWhite solid
      Hill FormulaC₃₇H₅₀N₂O₁₀&;bull;C₆H₈O₇
      Chemical formulaC₃₇H₅₀N₂O₁₀&;bull;C₆H₈O₇
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targeta7 AchR
      Primary Target K<sub>i</sub>1.4nM
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      505208 0

      Documentation

      Methyllycaconitine Citrate - CAS 21019-30-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Suzuki, S., et al. 2013. J. Neurosci. Res. 91, 462.
      Freitas, K., et al. 2013. Neuropharmacol. 65, 156.
      Sheeja, N., et al. 2012. Hippocampus. 22, 335.
      Xiong, Y., et al. 2010. Pharmacol. Biochem. & Beha. 95, 192.
      Whiteaker, P., et al. 1999. Eur. J. Neurosci. 11, 96.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-November-2015 JSW
      SynonymsAChR Receptor Antagonist, Methyllycaconitine Citrate, alpha7beta2 recptor Antagonist, Methyllycaconitine Citrate, Methyllycaconitine; α7-Nicotinic Receptor Antagonist, Methyllycaconitine Citrate, Neuronal Nicotinic Receptor Antagonist, Methyllycaconitine Citrate
      DescriptionA potent antagonist highly selective for AChRs with α7 subunit (Ki = 1.4 nM for α7 subunit and > 40 nM for α4β2 and α6β2 receptors). Frequently used in assessing the functional roles of AChRs with α7 subunit in brain functions and disorders (i.e. inflammatory and chronic neuropathic pain and parkinsonian neurodegeneration).
      FormWhite solid
      CAS number21019-30-7
      Chemical formulaC₃₇H₅₀N₂O₁₀&;bull;C₆H₈O₇
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSuzuki, S., et al. 2013. J. Neurosci. Res. 91, 462.
      Freitas, K., et al. 2013. Neuropharmacol. 65, 156.
      Sheeja, N., et al. 2012. Hippocampus. 22, 335.
      Xiong, Y., et al. 2010. Pharmacol. Biochem. & Beha. 95, 192.
      Whiteaker, P., et al. 1999. Eur. J. Neurosci. 11, 96.