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FCABS326PE Milli-Mark® Anti-acetyl-Histone H4 Antibody-PE

Milli-Mark® Anti-acetyl-Histone H4 Antibody-PE is a highly specific rabbit polyclonal antibody, that targets Histone H4 & has been tested in Flow Cytometry.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function, Epigenetics & Nuclear Function Research Sub-Category: Histone Modifying Proteins, Histones Gene Symbol: HHF1, HHF2 UniProt Number: P69152
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FCABS326PE
100 tests  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCRbPhycoerythrinPolyclonal Antibody
      Description
      Catalogue NumberFCABS326PE
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark® Anti-acetyl-Histone H4 Antibody-PE
      Alternate Names
      • Histone H4
      Background InformationHistone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Acetylation of histone H4 occurs at several different lysine positions in the histone tail and is performed by a family of enzymes known as Histone Acetyl Transferases (HATs).
      References
      Product Information
      FormatPhycoerythrin
      Control
      • HeLa cells
      PresentationPurified rabbit polyclonal IgG conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationMilli-Mark® Anti-acetyl-Histone H4 Antibody-PE is a highly specific rabbit polyclonal antibody, that targets Histone H4 & has been tested in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenTetrahymena histone H4 acetylated on lysines 5, 8, 12, and 16.
      HostRabbit
      SpecificityRecognizes acetylated histone H4. Cross-reacts with acetylated histone H2B from Tetrahymena and weakly cross-reacts with acetylated histone H2B from HeLa cells. May crossreact with other acetylated proteins.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element [provided by RefSeq].
      Gene Symbol
      • HHF1
      • HHF2
      Modifications
      • Acetylation
      • Acetylation
      • Acetylation
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

      SIZE: 103 amino acids; 11367 Da

      SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

      SUBCELLULAR LOCATION: Nucleus.

      PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.

      SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family.
      Molecular Weight11 kDa Calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      FCABS326PE 04053252820663

      Documentation

      Milli-Mark® Anti-acetyl-Histone H4 Antibody-PE SDS

      Title

      Safety Data Sheet (SDS) 

      Milli-Mark® Anti-acetyl-Histone H4 Antibody-PE Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-acetyl-Histone H4-PE - Q2120878 Q2120878
      Milli-Mark™ Anti-acetyl-Histone H4-PE 2480971
      Milli-Mark™ Anti-acetyl-Histone H4-PE - 3601743 3601743
      Milli-Mark™ Anti-acetyl-Histone H4-PE - 3698190 3698190
      Milli-Mark™ Anti-acetyl-Histone H4-PE - 3928036 3928036
      Milli-Mark™ Anti-acetyl-Histone H4-PE - 4122166 4122166
      Milli-Mark™ Anti-acetyl-Histone H4-PE - 4219995 4219995
      Milli-Mark™ Anti-acetyl-Histone H4-PE -2594451 2594451
      Milli-Mark™ Anti-acetyl-Histone H4-PE -2608860 2608860
      Milli-Mark™ Anti-acetyl-Histone H4-PE -2649274 2649274
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