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MAC131-25UG Mouse anti-Camelid IgG2/3 (heavy chain) Antibody, clone P17JE11

Mouse anti-Camelid IgG2/3 (heavy chain), clone P17JE11 detects Camelid IgG2/igG3 heavy chain. It has been tested for use in ELISA.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Secondary & Control Antibodies UniProt Number: 0
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MAC131-25UG
25 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      CamelidELISAMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAC131-25UG
      DescriptionMouse anti-Camelid IgG2/3 (heavy chain) Antibody, clone P17JE11
      Alternate Names
      • HCAbs
      • Camelid antibody
      Background InformationCamelidae family that includes camels and llamas are the only mammals reported to have heavy-chain (IgG-like) antibodies. Camelids produce conventional antibodies, but they also produce antibodies that do not associate with light chains. They produce functional antibodies devoid of light chains of which the single N-terminal domain is fully capable of antigen binding. Their VHH domain is located on a single stretch of amino acids and retains its antigen-recognition capability. Their heavy chains are devoid of the CH1 domain and have modified VH domain. Camelid heavy-chain antibodies (HCAbs) comprise about 50% of serum IgG in Llama and about 75% in Camelus species. HCAbs exhibit a molecular mass of about 100 kDa, which is smaller than conventional IgG1 and allows it to bind epitopes that may not be accessible to conventional antibodies. Also, the smaller size and single domain make it easier to transform them into bacterial cells for larger production needs. HCAbs are reported to display similar specificities, but are more robust in some cases. (Ref.: Daley LP et al. (2010). Clin. Vaccine Immunol. 17(2); 239-246; Harmsen, MM., and De Haard, HJ (2007) Appl Microbiol Biotechnol 77(1):13-22).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationMouse anti-Camelid IgG2/3 (heavy chain), clone P17JE11 detects Camelid IgG2/igG3 heavy chain. It has been tested for use in ELISA.
      Key Applications
      • ELISA
      Biological Information
      ImmunogenCamelid heavy-chain immunoglobulin G (clgG2/3).
      CloneP17JE11
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone P17JE11 detects Camelid IgG2/igG3 heavy chain. Displays trivial to none reactivity with other species.
      IsotypeIgG1κ
      Species Reactivity
      • Camelid
      Species Reactivity NoteCamel, Llama
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein G purified
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by ELISA in IgG as tested in various species.

      ELISA Analysis: 2 µg/mL of this antibody detected Camelid IgG2/3 (heavy chain).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAC131-25UG 04054839553639