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855029 N-Cyclohexylcarbodiimide,N'-methyl polystyrene

Novabiochem®

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 9003-70-7
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855029
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Overview

Replacement Information

Key Spec Table

CAS #
9003-70-7
Description
Catalogue Number855029
Replaces01-64-0211
Brand Family Novabiochem®
Background InformationN-Cyclohexylcarbodiimide,N'-methyl polystyrene [1] is an ideal tool for mediating solution phase coupling reactions. Typically, the amine and carboxylic acid are treated with a 2-3 fold excess of resin in DCM or DMF [2, 3]; a slight excess of carboxyl component over amine component is often used to help drive the reaction to completion. As excess acid and urea by-products remain attached to the resin at the end of the reaction, the product can normally be isolated pure by filtration and evaporation of the reaction mixture. Reactions can be accelerated by the addition of auxiliary nucleophiles such as HOBt; these can be removed using polyamine- or TBD-polystyrene. This resin has also been used in conjunction with DMAP to mediate ester formation [4].

The product number for this product was previously 01-64-0211.

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References
Product Information
CAS number9003-70-7
HS Code3903 90 90
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 1 slightly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)slightly beige to brown
Appearance of substance (visual)beads
Loading (determined by HPLC after reaction of Z-Phe-OH with cyclohexylamine)≥ 1.3 mmol/g
Swelling Volume (in CH₂Cl₂)lot specific result
The polymer matrix is copoly (styrene-2 % DVB), 200 - 400 mesh.

Documentation

N-Cyclohexylcarbodiimide,N'-methyl polystyrene SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] G.M Weinshenker, et al. (1988) Org. Synth., Coll. Vol. VI, 951.
  • [2] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
  • [3] K. Senton, et al. (2003) J. Comb. Chem., 5, 336.
  • [4] M. Cano, et al. (2002) J. Org. Chem., 67, 129.