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481919 NAADP Receptor Modulator

NAADP Receptor Modulator MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-Carbamoylmethyl-3-carboxy-pyridinium iodide

481919
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      A cell-permeable nicotinic acid analog that acts as a selective antagonist of NAADP-induced Ca2+ release, while at higher concentrations, also exhibits weak agonistic property towards NAADPR (nicotinic acid adenine dinucleotide phosphate receptor). A weak NAADPR ligand (IC50 = 90 µM in competition binding against 0.2 nM NAADP) that specifically inhibits NAADP-mediated, but not cADPR-, IP3-, or Acetylcholine-evoked, Ca2+ response in sea urchin egg homogenate and in murine pancreatic acinar cells.
      Catalogue Number481919
      Brand Family Calbiochem®
      Synonyms1-Carbamoylmethyl-3-carboxy-pyridinium iodide
      References
      ReferencesDowden, J., et al. 2006. Chem. Biol. 13, 659.
      Product Information
      CAS number854091-96-6
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₈H₉IN₂O₃
      Chemical formulaC₈H₉IN₂O₃
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetSelective antagonist of NAADP-induced Ca2+ release
      Primary Target IC<sub>50</sub>90 µM in competition binding against 0.2 nM NAADP
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      481919 0

      Documentation

      NAADP Receptor Modulator SDS

      Title

      Safety Data Sheet (SDS) 

      NAADP Receptor Modulator Certificates of Analysis

      TitleLot Number
      481919

      References

      Reference overview
      Dowden, J., et al. 2006. Chem. Biol. 13, 659.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms1-Carbamoylmethyl-3-carboxy-pyridinium iodide
      DescriptionA cell-permeable nicotinic acid analog that acts as a selective antagonist of NAADP-induced Ca2+ release, while at higher concentrations, also exhibits weak agonistic property towards NAADPR (nicotinic acid adenine dinucleotide phosphate receptor). A weak NAADPR ligand (IC50 = 90 µM in competition binding against 0.2 nM NAADP) that specifically inhibits NAADP-mediated, but not cADPR-, IP3-, or Acetylcholine-evoked, Ca2+ response in sea urchin egg homogenate and in murine pancreatic acinar cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number854091-96-6
      Chemical formulaC₈H₉IN₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml) or H₂O (100 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Irritant
      ReferencesDowden, J., et al. 2006. Chem. Biol. 13, 659.