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481414 NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem

The NF-κB Activation Inhibitor VI, BOT-64, also referenced under CAS 113760-29-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      113760-29-5C₁₅H₁₅NO₂S
      Description
      OverviewA cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation and nitrite production (IC50 = 1.0 & 0.7 µM, respectively) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice (70% survival rate with 30 mg/kg BOT-64, i.p.) in vivo.
      Catalogue Number481414
      Brand Family Calbiochem®
      Synonyms6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one
      References
      ReferencesKim, B.H., et al. 2008. Mol. Pharmacol. 73, 1309.
      Product Information
      CAS number113760-29-5
      FormOff-white solid
      Hill FormulaC₁₅H₁₅NO₂S
      Chemical formulaC₁₅H₁₅NO₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      481414 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Kim, B.H., et al. 2008. Mol. Pharmacol. 73, 1309.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one
      DescriptionA cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation and nitrite production (IC50 = 1.0 & 0.7 µM, respectively) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice (70% survival rate with 30 mg/kg BOT-64, i.p.) in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number113760-29-5
      Chemical formulaC₁₅H₁₅NO₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesKim, B.H., et al. 2008. Mol. Pharmacol. 73, 1309.