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480403 NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem

The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Inhibitor of NFAT-Calcineurin Association-6, INCA-6

Primary Target: Calcineurin-NFAT
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480403
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
3519-82-2C₂₀H₁₂O₂

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      Description
      OverviewA cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.
      Catalogue Number480403
      Brand Family Calbiochem®
      SynonymsInhibitor of NFAT-Calcineurin Association-6, INCA-6
      References
      ReferencesRoehrl, M.H.A., et al. 2004. Biochemistry 43, 16067.
      Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554.
      Product Information
      CAS number3519-82-2
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₀H₁₂O₂
      Chemical formulaC₂₀H₁₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCalcineurin-NFAT
      Primary Target IC<sub>50</sub>Kd = 800 nM for calcineurin-NFAT
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      480403-5MG 04055977201321

      Documentation

      NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      480403

      References

      Reference overview
      Roehrl, M.H.A., et al. 2004. Biochemistry 43, 16067.
      Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-October-2007 RFH
      SynonymsInhibitor of NFAT-Calcineurin Association-6, INCA-6
      DescriptionA cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 µM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.
      FormYellow solid
      CAS number3519-82-2
      Chemical formulaC₂₀H₁₂O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml). Use only fresh DMSO.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesRoehrl, M.H.A., et al. 2004. Biochemistry 43, 16067.
      Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554.