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492035 NSC 721648 - CAS 872726-44-8 - Calbiochem

NSC 721648 - CAS 872726-44-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Fluoro-2-(3,4-dimethoxyphenyl)benzothiazole, GW 610; PMX 610

492035
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      872726-44-8C₁₅H₁₂FNO₂S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable benzothiazole compound that exhibits potent in vitro antiproliferative activity against HCC 2998, IGROV1, MCF-7, MDA 468, SR, and T-47D (GI50 <1 nM), while showing much reduced effect against 50 other human tumor cells in a panel screening. Although it is a high affinity AhR ligand (IC50 = 25 nM; Ki = 6.8 nM in a TCDD competitive binding study) and a known CYP1A1 inducer, neither property can fully account for its antitumor activity.
      Catalogue Number492035
      Brand Family Calbiochem®
      Synonyms5-Fluoro-2-(3,4-dimethoxyphenyl)benzothiazole, GW 610; PMX 610
      References
      ReferencesAiello, S., et al. 2008. J. Med. Chem. 51, 5135.
      Mortimer, C.G., et al. 2006. J. Med. Chem. 49, 179.
      Product Information
      CAS number872726-44-8
      FormWhite crystalline solid
      Hill FormulaC₁₅H₁₂FNO₂S
      Chemical formulaC₁₅H₁₂FNO₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      492035 0

      Documentation

      NSC 721648 - CAS 872726-44-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NSC 721648 - CAS 872726-44-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      492035

      References

      Reference overview
      Aiello, S., et al. 2008. J. Med. Chem. 51, 5135.
      Mortimer, C.G., et al. 2006. J. Med. Chem. 49, 179.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-January-2009 RFH
      Synonyms5-Fluoro-2-(3,4-dimethoxyphenyl)benzothiazole, GW 610; PMX 610
      DescriptionA cell-permeable benzothiazole compound that exhibits potent in vitro antiproliferative activity against HCC 2998, IGROV1, MCF-7, MDA 468, SR, and T-47D (GI50 <1 nM), while showing much reduced effect against 50 other human tumor cells in a panel screening. Although it is a high affinity AhR ligand (IC50 = 25 nM; Ki = 6.8 nM in a TCDD competitive binding study) and a known CYP1A1 inducer, neither property can fully account for its antitumor activity.
      FormWhite crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number872726-44-8
      Chemical formulaC₁₅H₁₂FNO₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMF (10 mg/ml) or DMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAiello, S., et al. 2008. J. Med. Chem. 51, 5135.
      Mortimer, C.G., et al. 2006. J. Med. Chem. 49, 179.