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476880 Naltrindole, Hydrochloride

A cell-permeable, δ-selective opioid receptor antagonist (Ki = 0.031, 3.8, and 332.7 nM for δ, µ, and κ, respectively) and an inhibitor of cellular Akt signaling.

Naltrindole, Hydrochloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NTI

Primary Target: δ-selective opioid receptor
476880
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
111469-81-9C₂₆H₂₆N₂O₃ • HCl
Description
Overview

This product has been discontinued.





A cell-permeable, δ-selective opioid receptor antagonist (Ki = 0.031, 3.8, and 332.7 nM for δ, µ, and κ, respectively) and an inhibitor of cellular Akt signaling. Decreases the cellular phosphorylation level of PDK1, Akt, FKHR/AFX, GSK-3β, and inhibits Akt-dependent cell growth in small cell lung cancer (SCLC) cell lines (IC50 = 25, 40, and 55 µM in NCI-H69, NCI-H345, and NCI-H510, respectively).
Catalogue Number476880
Brand Family Calbiochem®
SynonymsNTI
References
ReferencesChen, Y.L., et al. 2004. Cancer Res. 64, 8723.
Arakawa, K., et al. 1992. Transplantation 53, 951.
Portoghese, P.S., et al. 1991. J. Med. Chem. 34, 1715.
Portoghese, P.S., et al. 1988. Eur. J. Pharmacol. 146, 185.
Product Information
CAS number111469-81-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₆H₂₆N₂O₃ • HCl
Chemical formulaC₂₆H₂₆N₂O₃ • HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetδ-selective opioid receptor
Primary Target K<sub>i</sub>0.031, 3.8, and 332.7 nM for δ, µ, and κ, opioid receptor, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
476880 0

Documentation

Naltrindole, Hydrochloride Certificates of Analysis

TitleLot Number
476880

References

Reference overview
Chen, Y.L., et al. 2004. Cancer Res. 64, 8723.
Arakawa, K., et al. 1992. Transplantation 53, 951.
Portoghese, P.S., et al. 1991. J. Med. Chem. 34, 1715.
Portoghese, P.S., et al. 1988. Eur. J. Pharmacol. 146, 185.

Brochure

Title
Akt
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-August-2008 RFH
SynonymsNTI
DescriptionA cell-permeable, δ-selective opioid receptor antagonist (Ki = 31 pM, 3.8 nM, and 332.7 nM for δ, µ, and κ receptors, respectively). Also inhibits cellular Akt signaling by decreasing the cellular phosphorylation levels of PDK1, Akt, FKHR/AFX, GSK-3β. Inhibits Akt-dependent cell growth in small cell lung cancer (SCLC) cell lines (IC50 = 25, 40, and 55 µM in NCI-H69, NCI-H345, and NCI-H510, respectively).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number111469-81-9
Chemical formulaC₂₆H₂₆N₂O₃ • HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (8 mg/ml) or Methanol (4.5 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesChen, Y.L., et al. 2004. Cancer Res. 64, 8723.
Arakawa, K., et al. 1992. Transplantation 53, 951.
Portoghese, P.S., et al. 1991. J. Med. Chem. 34, 1715.
Portoghese, P.S., et al. 1988. Eur. J. Pharmacol. 146, 185.