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476880 Naltrindole, Hydrochloride

A cell-permeable, δ-selective opioid receptor antagonist (Ki = 0.031, 3.8, and 332.7 nM for δ, µ, and κ, respectively) and an inhibitor of cellular Akt signaling.

Naltrindole, Hydrochloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NTI

Primary Target: δ-selective opioid receptor
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      111469-81-9C₂₆H₂₆N₂O₃ • HCl
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, δ-selective opioid receptor antagonist (Ki = 0.031, 3.8, and 332.7 nM for δ, µ, and κ, respectively) and an inhibitor of cellular Akt signaling. Decreases the cellular phosphorylation level of PDK1, Akt, FKHR/AFX, GSK-3β, and inhibits Akt-dependent cell growth in small cell lung cancer (SCLC) cell lines (IC50 = 25, 40, and 55 µM in NCI-H69, NCI-H345, and NCI-H510, respectively).
      Catalogue Number476880
      Brand Family Calbiochem®
      SynonymsNTI
      References
      ReferencesChen, Y.L., et al. 2004. Cancer Res. 64, 8723.
      Arakawa, K., et al. 1992. Transplantation 53, 951.
      Portoghese, P.S., et al. 1991. J. Med. Chem. 34, 1715.
      Portoghese, P.S., et al. 1988. Eur. J. Pharmacol. 146, 185.
      Product Information
      CAS number111469-81-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₂₆N₂O₃ • HCl
      Chemical formulaC₂₆H₂₆N₂O₃ • HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetδ-selective opioid receptor
      Primary Target K<sub>i</sub>0.031, 3.8, and 332.7 nM for δ, µ, and κ, opioid receptor, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      476880 0

      Documentation

      Naltrindole, Hydrochloride Certificates of Analysis

      TitleLot Number
      476880

      References

      Reference overview
      Chen, Y.L., et al. 2004. Cancer Res. 64, 8723.
      Arakawa, K., et al. 1992. Transplantation 53, 951.
      Portoghese, P.S., et al. 1991. J. Med. Chem. 34, 1715.
      Portoghese, P.S., et al. 1988. Eur. J. Pharmacol. 146, 185.

      Brochure

      Title
      Akt
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      SynonymsNTI
      DescriptionA cell-permeable, δ-selective opioid receptor antagonist (Ki = 31 pM, 3.8 nM, and 332.7 nM for δ, µ, and κ receptors, respectively). Also inhibits cellular Akt signaling by decreasing the cellular phosphorylation levels of PDK1, Akt, FKHR/AFX, GSK-3β. Inhibits Akt-dependent cell growth in small cell lung cancer (SCLC) cell lines (IC50 = 25, 40, and 55 µM in NCI-H69, NCI-H345, and NCI-H510, respectively).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number111469-81-9
      Chemical formulaC₂₆H₂₆N₂O₃ • HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (8 mg/ml) or Methanol (4.5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesChen, Y.L., et al. 2004. Cancer Res. 64, 8723.
      Arakawa, K., et al. 1992. Transplantation 53, 951.
      Portoghese, P.S., et al. 1991. J. Med. Chem. 34, 1715.
      Portoghese, P.S., et al. 1988. Eur. J. Pharmacol. 146, 185.