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504778 Nebivolol Hydrochloride - CAS 152520-56-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Narbivolol, rel-(aR,aʹR,2R,2ʹS)-a,aʹ-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride, β₁-Adrenoceptor Antagonist, Nebivolol Hydrochloride, Nebilet, R-65824

Primary Target: →₁-adrenoceptor
504778
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      152520-56-4C₂₂H₂₅F₂NO₄ • HCl
      Description
      Overview

      This product has been discontinued.



      A competitive, highly selective β1-adrenoceptor antagonist (more than 40-fold selective for β1 than β2; Ki1 and β2, respectively). The most β1-selective chemical of the β-blockers tested so far. Used for treatment of essential hypertension and highly cardioselective. Induces mild vasodialation via a nitric oxide- and cGMP-depedent pathways (EC50 = 11.36 µM in renal arteries).
      Catalogue Number504778
      Brand Family Calbiochem®
      SynonymsNarbivolol, rel-(aR,aʹR,2R,2ʹS)-a,aʹ-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride, β₁-Adrenoceptor Antagonist, Nebivolol Hydrochloride, Nebilet, R-65824
      References
      ReferencesPauwels, P., et al. 1988. Mol. Pharmacol. 34, 843.
      Georgescu, A., et al. 2007. Eur. J. Pharmacol. 570, 149.
      Georgescu, A., et al. 2008. Pharmacology 81, 110.
      Product Information
      CAS number152520-56-4
      FormWhite powder
      Hill FormulaC₂₂H₂₅F₂NO₄ • HCl
      Chemical formulaC₂₂H₂₅F₂NO₄ • HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target→₁-adrenoceptor
      Primary Target K<sub>i</sub>0.88 and 44 for →₁ and →₂, respectively.
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at-20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      504778 0

      Documentation

      Nebivolol Hydrochloride - CAS 152520-56-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Pauwels, P., et al. 1988. Mol. Pharmacol. 34, 843.
      Georgescu, A., et al. 2007. Eur. J. Pharmacol. 570, 149.
      Georgescu, A., et al. 2008. Pharmacology 81, 110.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-May-2013 JSW
      SynonymsNarbivolol, rel-(aR,aʹR,2R,2ʹS)-a,aʹ-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride, β₁-Adrenoceptor Antagonist, Nebivolol Hydrochloride, Nebilet, R-65824
      DescriptionA competitive, highly selective ?1-adrenoceptor antagonist (more than 40-fold selective for ?1 than ?2; Ki = 0.88 and 44 for ?1 and ?2, respectively). The most ?1-selective chemical of the ?-blockers tested so far. Used for treatment of essential hypertension and highly cardioselective. Induces mild vasodialation via a nitric oxide- and cGMP-depedent pathways (EC50 = 11.36 ?M in renal arteries).
      FormWhite powder
      CAS number152520-56-4
      Chemical formulaC₂₂H₂₅F₂NO₄ • HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/m)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at-20°C.
      Toxicity Standard Handling
      ReferencesPauwels, P., et al. 1988. Mol. Pharmacol. 34, 843.
      Georgescu, A., et al. 2007. Eur. J. Pharmacol. 570, 149.
      Georgescu, A., et al. 2008. Pharmacology 81, 110.