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488230 Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nogo Extracellular Peptide, 1-40, NEP1-40, Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH₂

Primary Target: Nogo-66 receptor (NgR)
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₀₆H₃₂₄N₅₆O₆₅
      Description
      Overview

      This product has been discontinued.



      An end-protected 40-mer peptide derived from the N-terminal fragment of the Nogo-66 domain that acts as a selective, competitive, high affinity antagonist of Nogo-66 receptor (NgR). Although NgR serves as the common receptor for both Nogo-66 and MAG (myelin-associated glycoprotein), NEP1-40 blocks only the inhibition of neurite outgrowth induced by Nogo-66, but not that by MAG. Promotes axonal regeneration after spinal cord injury in rats.
      Catalogue Number488230
      Brand Family Calbiochem®
      SynonymsNogo Extracellular Peptide, 1-40, NEP1-40, Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH₂
      References
      ReferencesGrandPré, T., et al. 2002. Nature 417, 547.
      Liu, B.P., et al. 2002. Science 297, 1190.
      Product Information
      ATP CompetitiveY
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₀₆H₃₂₄N₅₆O₆₅
      Chemical formulaC₂₀₆H₃₂₄N₅₆O₆₅
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNogo-66 receptor (NgR)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      488230 0

      Documentation

      Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem Certificates of Analysis

      TitleLot Number
      488230

      References

      Reference overview
      GrandPré, T., et al. 2002. Nature 417, 547.
      Liu, B.P., et al. 2002. Science 297, 1190.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-August-2008 RFH
      SynonymsNogo Extracellular Peptide, 1-40, NEP1-40, Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH₂
      DescriptionAn end-protected 40 amino acid peptide derived from the N-terminal fragment of the Nogo-66 domain that is normally expressed on the surface of oligodendrocytes. Acts as a selective, competitive, high affinity antagonist of Nogo-66 receptor (NgR). Although NgR serves as the common receptor for both Nogo-66 and myelin-associated glycoprotein (MAG), NEP1-40 blocks the inhibition of Nogo-66-induced neurite outgrowth, but not that of MAG. Promotes axonal regeneration following spinal cord injury in rats.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀₆H₃₂₄N₅₆O₆₅
      Peptide SequenceAc-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH₂
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGrandPré, T., et al. 2002. Nature 417, 547.
      Liu, B.P., et al. 2002. Science 297, 1190.