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492040 Nrf2 Activator - Calbiochem

The Nrf2 Activator modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Nrf2 Activator - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-1-(2-Methoxyphenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one, Nuclear factor-erythroid 2 p45-related factor 2 Activator, 2-Trifluoromethyl-2ʹ-methoxychalone, Antioxidant Response Element Activator II, ARE Activator II

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492040
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₇H₁₃F₃O₂
      Description
      OverviewA cell-permeable chalcone that effectively activates NQO1 (NADPH-/quinone oxidoreductase 1) ARE- (antioxidant response element) mediated reporter transcription in human bronchial epithelial Beas-2B cells (7.0-fold of control; 20 µM compound) and induces Nrf2- (Nuclear factor erythroid 2 p45-related factor 2) regulated antioxidants and cytoprotective genes transcription, including GCLM (glutamate-cysteine ligase modifier subunit), NQO1, and HO1 (heme oxygenase-1), both in cultures ([compound] = 10 to 20 µM) in vitro and in mice (50 mg/kg p.o.) in vivo.
      Catalogue Number492040
      Brand Family Calbiochem®
      Synonyms(E)-1-(2-Methoxyphenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one, Nuclear factor-erythroid 2 p45-related factor 2 Activator, 2-Trifluoromethyl-2ʹ-methoxychalone, Antioxidant Response Element Activator II, ARE Activator II
      References
      ReferencesKumar, V., et al. 2011. J. Med. Chem. 54, 4147.
      Product Information
      FormYellow syrup
      Hill FormulaC₁₇H₁₃F₃O₂
      Chemical formulaC₁₇H₁₃F₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      492040 0

      Documentation

      Nrf2 Activator - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Nrf2 Activator - Calbiochem Certificates of Analysis

      TitleLot Number
      492040

      References

      Reference overview
      Kumar, V., et al. 2011. J. Med. Chem. 54, 4147.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-May-2012 JSW
      Synonyms(E)-1-(2-Methoxyphenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one, Nuclear factor-erythroid 2 p45-related factor 2 Activator, 2-Trifluoromethyl-2ʹ-methoxychalone, Antioxidant Response Element Activator II, ARE Activator II
      DescriptionA cell-permeable chalcone that is shown to effectively activate NQO1 (NADPH/quinine oxidoreductase 1) ARE- (antioxidant response element) mediated reporter transcription in human bronchial epithelial Beas-2B cells (6.3- and 7.0-fold of control, respectively, with 10 and 20 µM compound) and induce Nrf2- (Nuclear factor erythroid 2 p45-related factor 2) regulated antioxidants and cytoprotective genes transcription, including GCLM (glutamate-cysteine ligase modifier subunit), NQO1, and HO1 (heme oxygenase-1), both in Beas-2B cultures (4-, 6.7-, and 178-fold, respectively, of basal NQO1/24 h, GCLM/6 h, and HO1/6 h mRNA level; [compound ] = 10 µM) in vitro and in mice (6- and 10-fold, respectively, of control GCLM and NQO1 mRNA level in small intestine 24 h after single p.o. dosage of 50 mg/kg) in vivo. The drug's cellular target(s) and mechanism of action is unknown, but likely involves covalent thio modification of the target(s) by the compound's electrophilic enone moiety.
      FormYellow syrup
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₃F₃O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesKumar, V., et al. 2011. J. Med. Chem. 54, 4147.