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492042 Nrf2 Activator III, TAT-14 Peptide - CAS 1362661-34-4 - Calbiochem

Nrf2 Activator III, TAT-14 Peptide, CAS 1362661-34-4, is a 14-mer peptide conjugated to cell-penetrating TAT sequence. Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH

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492042
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1362661-34-4C₁₃₇H₂₃₀N₄₈O₃₉

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      Description
      OverviewA 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75 µM). Also shown to suppress LPS-induced TNF-α secretion in THP-1 monocytes (~ 37.5 µM).
      Catalogue Number492042
      Brand Family Calbiochem®
      SynonymsH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH
      References
      ReferencesSteel, R., et al. 2012. ACS Med Chem Lett. 3, 407.
      Product Information
      CAS number1362661-34-4
      FormWhite powder
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₃₇H₂₃₀N₄₈O₃₉
      Chemical formulaC₁₃₇H₂₃₀N₄₈O₃₉
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      ApplicationNrf2 Activator III, TAT-14 Peptide, CAS 1362661-34-4, is a 14-mer peptide conjugated to cell-penetrating TAT sequence. Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2.
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide SequenceH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      492042-10MG 04055977272789

      Documentation

      Nrf2 Activator III, TAT-14 Peptide - CAS 1362661-34-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Nrf2 Activator III, TAT-14 Peptide - CAS 1362661-34-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      492042

      References

      Reference overview
      Steel, R., et al. 2012. ACS Med Chem Lett. 3, 407.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-August-2012 JSW
      SynonymsH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH
      DescriptionA 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75 µM). Also shown to suppress LPS-induced TNF-α secretion in THP-1 monocytes (~ 37.5 µM).
      FormWhite powder
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1362661-34-4
      Chemical formulaC₁₃₇H₂₃₀N₄₈O₃₉
      Peptide SequenceH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSteel, R., et al. 2012. ACS Med Chem Lett. 3, 407.