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499050 Osteocalcin, Bovine Bone

Osteocalcin, Bovine Bone MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Bone-Gla-Protein, BGP

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499050
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Overview

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499050-100UG
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      		 Plastic ampoule 100 μg
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      Description
      OverviewSingle chain vitamin K-dependent protein produced by osteoblasts. Osteocalcin purified from bovine bone. Binds to phospholipid vesicles in the presence of Ca2+ (Kd = 6 µM). Also binds hydroxylapatite. A good marker of bone turnover. May play a role in bone mineralization, bone resorption, and bone formation.
      Catalogue Number499050
      Brand Family Calbiochem®
      SynonymsBone-Gla-Protein, BGP
      References
      ReferencesCarter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
      Watson, K.E., et al. 1994. J. Clin. Invest. 93, 2106.
      Tracy, R.P., et al. 1990. J. Bone Min. Res. 5, 451.
      Gendreau, M.A., et al. 1989. J. Biol. Chem. 264, 6972.
      Product Information
      FormLiquid
      FormulationIn 75 mM NaCl, 10 mM sodium phosphate buffer, pH 7.4.
      Hill FormulaC₂₆₃H₃₇₂N₆₆O₈₂S₂
      Chemical formulaC₂₆₃H₃₇₂N₆₆O₈₂S₂
      PI4.0 - 4.5
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by SDS-PAGE
      Physicochemical Information
      Peptide SequenceH-Tyr-Leu-Asp-His-Trp-Leu-Gly-Ala-Pro-Ala-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Lys-Arg-Gla-Val-Cys²³-Gla-Leu-Asn-Pro-Asp-Cys²⁹-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val-OH (disulfide bond: 23 → 29)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      499050-100UG 04055977199895

      Documentation

      Osteocalcin, Bovine Bone SDS

      Title

      Safety Data Sheet (SDS) 

      Osteocalcin, Bovine Bone Certificates of Analysis

      TitleLot Number
      499050

      References

      Reference overview
      Carter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
      Watson, K.E., et al. 1994. J. Clin. Invest. 93, 2106.
      Tracy, R.P., et al. 1990. J. Bone Min. Res. 5, 451.
      Gendreau, M.A., et al. 1989. J. Biol. Chem. 264, 6972.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-August-2008 RFH
      SynonymsBone-Gla-Protein, BGP
      DescriptionSingle chain vitamin K-dependent protein produced by osteoblasts. Osteocalcin purified from bovine bone. Binds to phospholipid vesicles in the presence of Ca2+ (Kd = 6 µM). Also binds hydroxylapatite. Possible role in bone mineralization, bone resorption, and bone formation. Note: Gla corresponds to γ-carboxyglutamic acid.
      FormLiquid
      FormulationIn 75 mM NaCl, 10 mM sodium phosphate buffer, pH 7.4.
      Chemical formulaC₂₆₃H₃₇₂N₆₆O₈₂S₂
      Peptide SequenceH-Tyr-Leu-Asp-His-Trp-Leu-Gly-Ala-Pro-Ala-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Lys-Arg-Gla-Val-Cys²³-Gla-Leu-Asn-Pro-Asp-Cys²⁹-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val-OH (disulfide bond: 23 → 29)
      Purity≥98% by SDS-PAGE
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesCarter, S.D., et al. 1996. J. Anim. Sci. 74, 2719.
      Watson, K.E., et al. 1994. J. Clin. Invest. 93, 2106.
      Tracy, R.P., et al. 1990. J. Bone Min. Res. 5, 451.
      Gendreau, M.A., et al. 1989. J. Biol. Chem. 264, 6972.