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612100 PARP Inhibitor X, TIQ-A

PARP Inhibitor X, TIQ-A MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4H-Thieno[2,3-c]isoquinolin-5-one

Primary Target: PARP-1 bovin recombinant
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      420849-22-5C₁₁H₇NOS
      Description
      Overview

      This product has been discontinued.





      A cell-permeable isoquinolinone compound that acts as a potent inhibitor of poly (ADP-ribose) polymerase-1 (IC50 = 450 nM for bovine recombinant PARP-1). Exhibits neuroprotective effects against ischemia both in vitro (IC50 = 150 nM in cultured murine cortical cells) and in vivo (3 mg/kg i.p. in a rat transient focal ischemia model). Reported to be ~20-fold more potent than DPQ (Cat. No. 300270).
      Catalogue Number612100
      Brand Family Calbiochem®
      Synonyms4H-Thieno[2,3-c]isoquinolin-5-one
      References
      ReferencesPellicciari, R., et al. 2003. Farmaco 58, 851.
      Chiarugi, A., et al. 2003. J. Pharmacol. Exp. Ther. 305, 943.
      Product Information
      CAS number420849-22-5
      FormOff-white to brown solid
      Hill FormulaC₁₁H₇NOS
      Chemical formulaC₁₁H₇NOS
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPARP-1 bovin recombinant
      Secondary targetIC₅₀ = 150 nM in cultured murine cortical cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      612100 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      References

      Reference overview
      Pellicciari, R., et al. 2003. Farmaco 58, 851.
      Chiarugi, A., et al. 2003. J. Pharmacol. Exp. Ther. 305, 943.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      Synonyms4H-Thieno[2,3-c]isoquinolin-5-one
      DescriptionA cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) (IC50 = 450 nM for bovine recombinant PARP-1). Reported to exhibit neuroprotective effects against ischemia in vitro (IC50 = 150 nM in cultured murine cortical cells) and in vivo (3 mg/kg i.p. in rat transient focal ischemia model). Also reported to be ~20-fold more potent than DPQ (Cat. No. 300270).
      FormOff-white to brown solid
      CAS number420849-22-5
      Chemical formulaC₁₁H₇NOS
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesPellicciari, R., et al. 2003. Farmaco 58, 851.
      Chiarugi, A., et al. 2003. J. Pharmacol. Exp. Ther. 305, 943.