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528118 PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem

PI 3-Kδ Inhibitor X, IC87114, CAS 371242-69-2, is a cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110, p110, and p110, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Phosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X

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528118
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
371242-69-2C₂₂H₁₉N₇O

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      Description
      OverviewA cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
      Catalogue Number528118
      Brand Family Calbiochem®
      SynonymsPhosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X
      References
      ReferencesBillottet, C., et al. 2009. Cancer Res. 69,1027.
      Ali, K., et al. 2008. J. Immunol. 180, 2538.
      Product Information
      CAS number371242-69-2
      FormWhite powder
      Hill FormulaC₂₂H₁₉N₇O
      Chemical formulaC₂₂H₁₉N₇O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationPI 3-Kδ Inhibitor X, IC87114, CAS 371242-69-2, is a cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110, p110, and p110, respectively).
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      528118-5MG 04055977197013

      Documentation

      PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      528118

      References

      Reference overview
      Billottet, C., et al. 2009. Cancer Res. 69,1027.
      Ali, K., et al. 2008. J. Immunol. 180, 2538.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-September-2010 RFH
      SynonymsPhosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X
      DescriptionA cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
      FormWhite powder
      CAS number371242-69-2
      Chemical formulaC₂₂H₁₉N₇O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBillottet, C., et al. 2009. Cancer Res. 69,1027.
      Ali, K., et al. 2008. J. Immunol. 180, 2538.