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12-123 PKC Substrate Peptide

PKC Substrate Peptide primarily used in Kinase Assays.

PKC Substrate Peptide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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12-123
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue Number12-123
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPKC Substrate Peptide
      References
      Product Information
      PresentationLyophilized powder
      Quality LevelMQ100
      Applications
      ApplicationPKC Substrate Peptide primarily used in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
      Gene Symbol
      • PRKCA
      • PKC-A
      • PKCA
      • MGC129901
      • AAG6
      • MGC129900
      • PRKACA
      • PKC-alpha
      Protein TargetPKC
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17252 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
      COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
      SIZE: 672 amino acids; 76764 Da
      SUBUNIT: Interacts with CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
      SIMILARITY: SwissProt: P17252 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated in an enzyme assay using PKC (14-115)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at 4°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      12-123 04053252509568

      Documentation

      PKC Substrate Peptide SDS

      Title

      Safety Data Sheet (SDS) 

      PKC Substrate Peptide Certificates of Analysis

      TitleLot Number
      PKC Substrate Peptide (MBP 4-14) - 2378754 2378754
      PKC Substrate Peptide (MBP 4-14) 2934604
      PKC Substrate Peptide (MBP 4-14) - 2262762 2262762
      PKC Substrate Peptide (MBP 4-14) - 3683138 3683138
      PKC Substrate Peptide (MBP 4-14) -2452677 2452677
      PKC Substrate Peptide - 15157 15157
      PKC Substrate Peptide - 15924 15924
      PKC Substrate Peptide - 17518 17518
      PKC Substrate Peptide - 20634 20634
      PKC Substrate Peptide - 2064523 2064523
      Show more

      References

      Reference overviewApplicationPub Med ID
      Nuclear diacylglycerol produced by phosphoinositide-specific phospholipase C is responsible for nuclear translocation of protein kinase C-alpha
      Neri, L. M., et al
      J Biol Chem, 273:29738-44 (1998)  1998

      		Kinase Assay9792687 9792687
      Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C
      Siow, Y. L., et al
      J Biol Chem, 272:7586-94 (1997)  1997

      		Kinase Assay9065412 9065412
      A synthetic peptide substrate for selective assay of protein kinase C.
      Yasuda, I, et al.
      Biochem. Biophys. Res. Commun., 166: 1220-7 (1990)  1990

      Show Abstract       		1689574 1689574

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      Categories

      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates