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529627 PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PiB, Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate

Primary Target: Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      64005-90-9C₂₂H₁₈N₂O₈
      Description
      Overview

      This product has been discontinued.



      A cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties (IC50 < 5 µM against a panel of human cancer cell lines). Causes cell cycle arrest and acts as a potent, selective, reversible, competitive, active site binding inhibitor of Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity (IC50 = ~ 1.5 µM). Does not bind to DNA or functions as a topoisomerase I inhibitor.
      Catalogue Number529627
      Brand Family Calbiochem®
      SynonymsPiB, Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
      References
      ReferencesUchida, T., et al. 2003. Chem. Biol. 10, 15.
      Product Information
      CAS number64005-90-9
      ATP CompetitiveY
      FormBrownish solid
      Hill FormulaC₂₂H₁₈N₂O₈
      Chemical formulaC₂₂H₁₈N₂O₈
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
      Primary Target IC<sub>50</sub>< 5 µM for anti-proliferative properties against a panel of human cancer cell lines; ~ 1.5 µM inhibiting Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity
      Purity≥95% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      529627 0

      Documentation

      PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Uchida, T., et al. 2003. Chem. Biol. 10, 15.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      SynonymsPiB, Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
      DescriptionA cell-permeable, napthalenetetracarboxylic-bismide compound that displays anti-proliferative properties (IC50 < 5 µM against a panel of human cancer cell lines). Causes cell cycle arrest and acts as a potent, selective, reversible, competitive, active site-binding inhibitor of Pin1/Par14 peptidylprolyl cis-trans isomerase (PPIase) activity (IC50 ~ 1.5 µM). Does not bind to DNA or function as a topoisomerase I inhibitor.
      FormBrownish solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number64005-90-9
      Chemical formulaC₂₂H₁₈N₂O₈
      Structure formulaStructure formula
      Purity≥95% by NMR
      SolubilityChloroform (1 mg/ml) or Ethanol (250 µg/ml, cloudy suspension)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesUchida, T., et al. 2003. Chem. Biol. 10, 15.