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525325 Phosphotyrosine Phosphatase Inhibitor Set (Vanadium)

525325
  
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      Overview

      Replacement Information

      Key Spec Table

      Description
      Overview

      This product has been discontinued.





      Contains 5 g of Sodium Orthovanadate (Cat. No. 567540), 10 mg each of bpV(phen) (Cat. No. 203695), and mpV(pic) (Cat. No. 475950).
      Catalogue Number525325
      Brand Family Calbiochem®
      References
      Product Information
      FormSolid
      Applications
      Biological Information
      Primary TargetNa+,K+-ATPase
      Secondary targetATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK2) of Salmonella typhimurium in the micromolar range
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Multiple Toxicity Values, refer to MSDS
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Phosphotyrosine Phosphatase Inhibitor Set (Vanadium) Certificates of Analysis

      TitleLot Number
      525325
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-June-2008 JSW
      DescriptionProtein Tyrosine Phosphatases (PTPs) and Protein Tyrosine Kinases (PTKs) are gene families encoding important proteins involved in signal transduction. PTPs can be classified as either tyrosine-specific or dual-specific based on their phosphatase activity. Diversity of PTP family includes both receptor -like transmembrane proteins and soluble cytosolic proteins. Each PTP contains a highly conserved catalytic domain of ~240 residues that share high sequence similarity throughout the family. The structures of PTP catalytic domains are highly conserved. Hence, the structural and functional diversity within the family depend on structures of noncatalytic regulatory and targeting domains attached to the N- and C- terminals of the catalytic domain. The catalytic site of PTP resides within a crevice on the molecule's surface. The base of the catalytic site is formed by the residues His214 through Arg221.

      PTP inhibitors serve as valuable tools in studying the functions of these enzymes as also serve as potential therapeutic agents. To assess the physiological function of PTPases, specific and selective inhibitors of peptidic and nonpeptidic nature have been developed.

      The Calbiochem® brand has assembled a set containing 3 inhibitors, which target phosphotyrosine phosphatase with different specificity, for your research needs.
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Toxicity Multiple Toxicity Values, refer to MSDS