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506152 Pifithrin-α, p-Nitro

Pifithrin-α, p-Nitro MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone, HBr

506152
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      389850-21-9C₁₅H₁₅N₃O₃S • HBr
      Description
      Overview

      This product has been discontinued.





      A cell-permeable p53 inhibitor that serves as the prodrug form of Pifithrin-α, p-Nitro, Cyclic (Cat. No. 506154). Although its in vitro efficacy (ED50 = 0.3 µM in protecting etoposide-induced cortical neuron death) is similar to that of Pifithrin-α (Cat. No. 506132), it is 100-fold more potent than Pifithrin-α when adminstered in rats in vivo due to its long-lasting, steady conversion to the corresponding cyclic form of active compound in biological systems (t1/2 = 8h in neuron culture medium at 37°C).
      Catalogue Number506152
      Brand Family Calbiochem®
      Synonyms1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone, HBr
      References
      ReferencesPietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.
      Product Information
      CAS number389850-21-9
      FormBeige solid
      Hill FormulaC₁₅H₁₅N₃O₃S • HBr
      Chemical formulaC₁₅H₁₅N₃O₃S • HBr
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      506152 0

      Documentation

      References

      Reference overview
      Pietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.

      Brochure

      Title
      p53 And Related Products
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone, HBr
      DescriptionA cell-permeable p53 inhibitor that serves as the prodrug form of Pifithrin-α, p-Nitro, Cyclic (Cat. No. 506154). Although its in vitro efficacy (ED50 = 0.3 µM in protecting etoposide-induced cortical neuron death) is similar to that of Pifithrin-α (Cat. No. 506132), it is 100-fold more potent than Pifithrin-α when adminstered in rats in vivo due to its long-lasting, steady conversion to the corresponding cyclic form of active compound in biological systems (t1/2 = 8h in neuron culture medium at 37°C).
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number389850-21-9
      Chemical formulaC₁₅H₁₅N₃O₃S • HBr
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (2.5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Standard Handling
      ReferencesPietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645.